S
Stanley Stasiewicz
Researcher at National Institutes of Health
Publications - 17
Citations - 1717
Stanley Stasiewicz is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Transgene & Nucleotide excision repair. The author has an hindex of 16, co-authored 17 publications receiving 1689 citations. Previous affiliations of Stanley Stasiewicz include Research Triangle Park.
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Journal ArticleDOI
Prediction of chemical carcinogenicity in rodents from in vitro genetic toxicity assays.
Raymond W. Tennant,Barry H. Margolin,Michael D. Shelby,Errol Zeiger,Joseph K. Haseman,Judson W. Spalding,William J. Caspary,Michael A. Resnick,Stanley Stasiewicz,Beth Anderson,Robert Minor +10 more
TL;DR: Four widely used in vitro assays for genetic toxicity were evaluated for their ability to predict the carcinogenicity of selected chemicals in rodents, indicating that chemicals positive in one in vitro assay tended to be positive in the other in vitro Assays.
Journal ArticleDOI
Systems toxicology and the Chemical Effects in Biological Systems (CEBS) knowledge base.
Michael D. Waters,Gary Boorman,Pierre R. Bushel,Michael L. Cunningham,Rick Irwin,Alex Merrick,Kenneth Olden,Richard S. Paules,Selkirk Jk,Stanley Stasiewicz,Brenda K. Weis,Ben Van Houten,Nigel J. Walker,Raymond W. Tennant +13 more
TL;DR: The National Center for Toxicogenomics is developing the first public toxicogenomics knowledge base that combines molecular expression data sets from transcriptomics, proteomics, metabonom-ics, and conventional toxicology with metabolic, toxicological pathway, and gene regulatory network information relevant to environmental toxicology and human disease.
Journal ArticleDOI
CEBS—Chemical Effects in Biological Systems: a public data repository integrating study design and toxicity data with microarray and proteomics data
Michael D. Waters,Stanley Stasiewicz,B. Alex Merrick,Kenneth B. Tomer,Pierre R. Bushel,Richard S. Paules,Nancy Stegman,Gerald J. Nehls,Kenneth J. Yost,C. Harris Johnson,Scott F. Gustafson,Sandhya Xirasagar,Nianqing Xiao,Cheng-Cheng Huang,Paul Boyer,Denny D. Chan,Qinyan Pan,Hui Gong,John Taylor,Danielle Choi,Asif Rashid,Ayazaddin Ahmed,Reese Howle,Selkirk Jk,Raymond W. Tennant,Jennifer Fostel +25 more
TL;DR: CEBS (Chemical Effects in Biological Systems) is an integrated public repository for toxicogenomics data, including the study design and timeline, clinical chemistry and histopathology findings and microarray and proteomics data.
Journal ArticleDOI
Prediction of the outcome of rodent carcinogenicity bioassays currently being conducted on 44 chemicals by the National Toxicology Program.
TL;DR: Evaluation of the concept that knowledge about chemical structure combined with limited short-term genotoxicity and toxicity test results can be used to predict potential carcinogens to enable others to make their own predictions before the results of the animal assays are known.
Journal ArticleDOI
Chemicals Showing No Evidence of Carcinogenicity in Long-Term, Two-Species Rodent Studies: The Need for Short-Term Test Data
TL;DR: A list of 70 chemicals that have been tested by the National Cancer Institute or the National Toxicology Program in long-term rodent carcinogenicity studies and that have yielded no evidence of cancer induction in male and female rats and mice is presented to document the shortage of STT results of noncarcinogens.