S
Stanton L. Gerson
Researcher at Case Western Reserve University
Publications - 371
Citations - 22045
Stanton L. Gerson is an academic researcher from Case Western Reserve University. The author has contributed to research in topics: Alkyltransferase & Stem cell. The author has an hindex of 72, co-authored 366 publications receiving 20944 citations. Previous affiliations of Stanton L. Gerson include University of Pennsylvania & Marshfield Clinic.
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Journal ArticleDOI
Rapid Hematopoietic Recovery After Coinfusion of Autologous-Blood Stem Cells and Culture-Expanded Marrow Mesenchymal Stem Cells in Advanced Breast Cancer Patients Receiving High-Dose Chemotherapy
Omer N. Koc,Stanton L. Gerson,Brenda W. Cooper,Stephanie M. Dyhouse,Stephen E. Haynesworth,Arnold I. Caplan,Hillard M. Lazarus +6 more
TL;DR: It is found that autologous MSC infusion at the time of PBPC transplantation is feasible and safe, and the observed rapid hematopoietic recovery suggests that M SC infusion after myeloablative therapy may have a positive impact on hematoiesis and should be tested in randomized trials.
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Phenotypic and functional comparison of cultures of marrow-derived mesenchymal stem cells (MSCs) and stromal cells
TL;DR: The morphology, phenotype, and in vitro function of cultures of MSCs and traditional marrow‐derived stromal cells (MDSCs) from the same marrow sample are examined to suggest that M SCs represent an important cellular component of the bone marrow microenvironment.
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Cotransplantation of HLA-identical sibling culture-expanded mesenchymal stem cells and hematopoietic stem cells in hematologic malignancy patients
Hillard M. Lazarus,Omer N. Koc,Steven M. Devine,Peter T. Curtin,Richard T. Maziarz,H. Kent Holland,Elizabeth J. Shpall,Philip L. McCarthy,Kerry Atkinson,Brenda W. Cooper,Stanton L. Gerson,Mary J. Laughlin,Fausto R. Loberiza,Annemarie Moseley,Andrea Bacigalupo +14 more
TL;DR: Cotransplantation of HLA-identical sibling culture-expanded MSCs with an HLA and hematopoietic HSC transplant is feasible and seems to be safe, without immediate infusional or late MSC-associated toxicities.
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Hematopoietic Engraftment and Survival in Adult Recipients of Umbilical-Cord Blood from Unrelated Donors
Mary J. Laughlin,Juliet N. Barker,Barbara Bambach,Omer N. Koc,David A. Rizzieri,John E. Wagner,Stanton L. Gerson,Hillard M. Lazarus,Mitchell S. Cairo,Cladd E. Stevens,Pablo Rubinstein,Joanne Kurtzberg +11 more
TL;DR: Umbilical-cord blood from unrelated donors can restore hematopoiesis in adults who receive myeloablative therapy and is associated with acceptable rates of severe acute and chronic GVHD.
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MGMT: its role in cancer aetiology and cancer therapeutics.
TL;DR: The DNA-repair protein O6-alkylguanine DNA alkyltransferase (AGT) has a wide range of activity in normal tissues and its evolutionary conservation indicates a fundamental role in cell physiology and maintenance of the genome.