Steen Dissing

TL;DR: In this article, the authors report that members of the PDGF family act as lymphangiogenic factors, and that PDGF-BB stimulated MAP kinase activity and cell motility of isolated lymphatic endothelial cells.

TL;DR: It is demonstrated that PlGF-1, an alternatively spliced isoform of the PlGF gene, antagonizes VEGF-induced angiogenesis when both factors are coexpressed in murine fibrosarcoma cells, and acts as a natural antagonist of V EGF when both Factors are synthesized in the same population of cells.

TL;DR: 1,25(OH)(2)D(3) increased intracellular calcium concentration, sperm motility and induced the acrosome reaction in mature spermatozoa, and VD serum levels were positively associated with sperm motilities, suggesting a role for VD in human sperm function.

TL;DR: It is shown that FGF-2 and VEGF-C collaboratively promote angiogenesis and lymphangiogenesis in the tumor microenvironment, leading to widespread pulmonary and lymph-node metastases and intervention and targeting of the F GF-2– and VGF-C–induced angiogenic andymphangiogenic synergism could be potentially important approaches for cancer therapy and prevention of metastasis.

TL;DR: The results indicate that CXCR3-γ IP-10 and -Mig receptor-ligand pairs as well as the effects of IL-2 and IL-10 on them may be especially important in the cytokine/chemokine environment for the pathophysiologic events of allergic inflammation, including initiation, progression, and termination in the processes.