Stefan M. Kren

TL;DR: Eight constructs decellularized hearts by coronary perfusion with detergents, preserved the underlying extracellular matrix, and produced an acellular, perfusable vascular architecture, competent a cellular valves and intact chamber geometry that could generate pump function in a modified working heart preparation.

TL;DR: Aldosterone contributes to hypertension and renal injury in the remnant kidney model and the response of aldosterone to drugs interfering with the RAAS is assessed.

TL;DR: Test the hypothesis that renal stem cells exist in the adult kidney and participate in the repair process by isolating a unique population of cells isolated from rat kidneys, which exhibit plasticity that is demonstrated by the ability of the cells to be induced to express endothelial, hepatocyte, and neural markers.

TL;DR: It is demonstrated that the preservation of renal function with dietary protein restriction after established glomerular injury follows upon reduction ofglomerular capillary hydraulic pressure, despite constancy of single nephron filtration rate and plasma flow and persistence of arterial hypertension.

TL;DR: Decellularization of human hearts provides a biocompatible scaffold that retains 3-dimensional architecture and vascularity and that can be recellularized with parenchymal and vascular cells.