Dietary protein restriction in established renal injury in the rat. Selective role of glomerular capillary pressure in progressive glomerular dysfunction.
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It is demonstrated that the preservation of renal function with dietary protein restriction after established glomerular injury follows upon reduction ofglomerular capillary hydraulic pressure, despite constancy of single nephron filtration rate and plasma flow and persistence of arterial hypertension.Abstract:Â
Dietary protein restriction imposed before renal injury is established in the remnant kidney model in the rat reduces glomerular hypertension and hyperperfusion and renal injury. We demonstrate that dietary protein restriction (6% vs. 20%) imposed on a background of established renal injury in the remnant model leads to a greater preservation of renal function as measured by glomerular filtration rate and fractional clearances of albumin and IgG, despite the persistence of systemic hypertension. In similarly prepared rats, dietary protein restriction (6% vs. 20%) led to a lower glomerular capillary hydraulic pressure, a higher ultrafiltration coefficient, and similar single nephron filtration rates. In addition, less impairment of glomerular permselectivity was demonstrable after protein restriction. Our data demonstrate that the preservation of renal function with dietary protein restriction after established glomerular injury follows upon reduction of glomerular capillary hydraulic pressure, despite constancy of single nephron filtration rate and plasma flow and persistence of arterial hypertension.read more
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Panayotis Kontessis,Sharon L. Jones,Sharon L. Jones,Rosemary Dodds,Rosemary Dodds,Roberto Trevisan,Roberto Trevisan,Romano Nosadini,Romano Nosadini,Paola Fioretto,Paola Fioretto,Mauro Borsato,Mauro Borsato,Davide Sacerdoti,Davide Sacerdoti,Giancarlo Viberti,Giancarlo Viberti +16 more
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References
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Dietary Protein Intake and the Progressive Nature of Kidney Disease: The Role of Hemodynamically Mediated Glomerular Injury in the Pathogenesis of Progressive Glomerular Sclerosis in Aging, Renal Ablation, and Intrinsic Renal Disease
TL;DR: With the development and increasingly widespread availability of dialysis and transplantation in the past three decades, relatively little attention has been paid to the influence of diet on the progression of renal disease, despite general awareness that renal disease typically follows an inexorably progressive course.
Journal ArticleDOI
Hyperfiltration in remnant nephrons : A potentially adverse response to renal ablation
TL;DR: In this article, a study was performed in three groups of male Munich-Wistar rats 1 wk after surgery: group I, eight control rats that underwent laparotomy and were fed a normal diet.
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Clinical diagnosis and management by laboratory methods
TL;DR: The Clinical Laboratory: Organization, Purpose and Practice Physician Office Laboratories (POLS) Principles of Instrumentation Clinical Laboratory Automation Interpreting Laboratory Results Informatics, Imaging and Interoperability Laboratory Statistics Clinical Laboratory Quality Assurance
Journal ArticleDOI
Control of glomerular hypertension limits glomerular injury in rats with reduced renal mass.
TL;DR: It is suggested that control of glomerular hypertension effectively limits glomersular injury in rats with renal ablation, and the view thatglomerular hemodynamic changes mediate progressive renal injury when nephron number is reduced is supported.
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The case for intrarenal hypertension in the initiation and progression of diabetic and other glomerulopathies.
TL;DR: A number of clinical studies have been performed in an attempt to dissect the particular component or components of the diabetic state responsible for these early elevations in glomerular filtration rate, and no single factor appears to account fully for this phenomenon.