T
Troy C. Lund
Researcher at University of Minnesota
Publications - 179
Citations - 13564
Troy C. Lund is an academic researcher from University of Minnesota. The author has contributed to research in topics: Transplantation & Medicine. The author has an hindex of 35, co-authored 149 publications receiving 12390 citations. Previous affiliations of Troy C. Lund include Vanderbilt University Medical Center.
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Journal ArticleDOI
Pluripotency of mesenchymal stem cells derived from adult marrow
Yuehua Jiang,Balkrishna N. Jahagirdar,R. Lee Reinhardt,Robert E. Schwartz,C. Dirk Keene,Xilma R. Ortiz-Gonzalez,Morayma Reyes,Todd Lenvik,Troy C. Lund,Mark Blackstad,Jingbo Du,Sara Aldrich,Aaron Lisberg,Walter C. Low,David A. Largaespada,Catherine M. Verfaillie +15 more
TL;DR: It is reported here that cells co-purifying with mesenchymal stem cells—termed here multipotent adult progenitor cells or MAPCs—differentiate, at the single cell level, not only into meschymal cells, but also cells with visceral mesoderm, neuroectoderm and endoderm characteristics in vitro.
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Purification and ex vivo expansion of postnatal human marrow mesodermal progenitor cells
TL;DR: MPCs that proliferate without obvious senescence under clinically applicable conditions and differentiate at the single-cell level not only into mesenchymal cells but also cells of visceral mesoderm may be an ideal source of stem cells for treatment of genetic or degenerative disorders affecting cells of mesodermal origin.
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Multipotent adult progenitor cells from bone marrow differentiate into functional hepatocyte-like cells.
Robert E. Schwartz,Morayma Reyes,Lisa Koodie,Yuehua Jiang,Mark Blackstad,Troy C. Lund,Todd Lenvik,Sandra Johnson,Wei Shou Hu,Catherine M. Verfaillie +9 more
TL;DR: MAPCs, derived from normal human, mouse, and rat postnatal bone marrow primitive, multipotent adult progenitor cells, can differentiate into cells with morphological, phenotypic, and functional characteristics of hepatocytes, and may be an ideal cell for in vivo therapies for liver disorders or for use in bioartificial liver devices.
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Hematopoietic Stem-Cell Gene Therapy for Cerebral Adrenoleukodystrophy
Florian Eichler,Christine Duncan,Patricia L. Musolino,Paul J. Orchard,Satiro N. De Oliveira,Adrian J. Thrasher,Myriam Armant,Colleen Dansereau,Troy C. Lund,Weston P. Miller,Gerald V. Raymond,Raman Sankar,Ami J. Shah,Caroline Sevin,H. Bobby Gaspar,Paul Gissen,Hernan Amartino,Drago Bratkovic,Nicholas J.C. Smith,Asif M. Paker,Esther Shamir,Tara O'Meara,David Davidson,Patrick Aubourg,David A. Williams +24 more
TL;DR: Early results of this study suggest that Lenti‐D gene therapy may be a safe and effective alternative to allogeneic stem‐cell transplantation in boys with early‐stage cerebral adrenoleukodystrophy.
Journal ArticleDOI
Bone Marrow Transplantation for Recessive Dystrophic Epidermolysis Bullosa
John E. Wagner,Akemi Ishida-Yamamoto,John A. McGrath,Maria K. Hordinsky,Douglas R. Keene,David T. Woodley,Mei Chen,Megan J. Riddle,Mark J. Osborn,Troy C. Lund,Michelle M Dolan,Bruce R. Blazar,Jakub Tolar +12 more
TL;DR: Increased C7 deposition and a sustained presence of donor cells were found in the skin of children with recessive dystrophic epidermolysis bullosa after allogeneic bone marrow transplantation, and further studies are needed to assess the long-term risks and benefits of such therapy in patients with this disorder.