S
Stefan M. Kren
Researcher at University of Minnesota
Publications - 37
Citations - 4738
Stefan M. Kren is an academic researcher from University of Minnesota. The author has contributed to research in topics: Decellularization & Kidney. The author has an hindex of 21, co-authored 37 publications receiving 4364 citations.
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Journal ArticleDOI
Perfusion-decellularized matrix: using nature's platform to engineer a bioartificial heart
Harald C. Ott,Thomas S Matthiesen,Saik Kia Goh,Lauren D. Black,Stefan M. Kren,Theoden I. Netoff,Doris A. Taylor +6 more
TL;DR: Eight constructs decellularized hearts by coronary perfusion with detergents, preserved the underlying extracellular matrix, and produced an acellular, perfusable vascular architecture, competent a cellular valves and intact chamber geometry that could generate pump function in a modified working heart preparation.
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Role of aldosterone in the remnant kidney model in the rat
TL;DR: Aldosterone contributes to hypertension and renal injury in the remnant kidney model and the response of aldosterone to drugs interfering with the RAAS is assessed.
Journal ArticleDOI
Isolation and Characterization of Kidney-Derived Stem Cells
Sandeep Gupta,Catherine M. Verfaillie,David Chmielewski,Stefan M. Kren,Keith E. Eidman,Jeffrey J. Connaire,Yves Heremans,Troy C. Lund,Mark Blackstad,Yuehua Jiang,Aernout Luttun,Mark E. Rosenberg +11 more
TL;DR: Test the hypothesis that renal stem cells exist in the adult kidney and participate in the repair process by isolating a unique population of cells isolated from rat kidneys, which exhibit plasticity that is demonstrated by the ability of the cells to be induced to express endothelial, hepatocyte, and neural markers.
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Dietary protein restriction in established renal injury in the rat. Selective role of glomerular capillary pressure in progressive glomerular dysfunction.
TL;DR: It is demonstrated that the preservation of renal function with dietary protein restriction after established glomerular injury follows upon reduction ofglomerular capillary hydraulic pressure, despite constancy of single nephron filtration rate and plasma flow and persistence of arterial hypertension.
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Acellular human heart matrix: A critical step toward whole heart grafts.
Pedro L. Sánchez,M. Eugenia Fernández-Santos,Salvatore Costanza,Andreu M. Climent,Isabel Moscoso,M. Angeles Gonzalez-Nicolas,Ricardo Sanz-Ruiz,Hugo Rodríguez,Stefan M. Kren,Gregorio Garrido,Jose Luis Escalante,Javier Bermejo,Jaime Elízaga,Javier Menarguez,Raquel Yotti,Candelas Pérez del Villar,M. Ángeles Espinosa,Maria S. Guillem,James T. Willerson,Antonio Bernad,Rafael Matesanz,Doris A. Taylor,Doris A. Taylor,Francisco Fernández-Avilés +23 more
TL;DR: Decellularization of human hearts provides a biocompatible scaffold that retains 3-dimensional architecture and vascularity and that can be recellularized with parenchymal and vascular cells.