S
Stefan Mansourian
Researcher at Brigham and Women's Hospital
Publications - 3
Citations - 1549
Stefan Mansourian is an academic researcher from Brigham and Women's Hospital. The author has contributed to research in topics: Insulin & Insulin-degrading enzyme. The author has an hindex of 3, co-authored 3 publications receiving 1441 citations. Previous affiliations of Stefan Mansourian include Harvard University.
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Journal ArticleDOI
Insulin-degrading enzyme regulates the levels of insulin, amyloid β-protein, and the β-amyloid precursor protein intracellular domain in vivo
Wesley Farris,Stefan Mansourian,Yang Chang,Loren Lindsley,Elizabeth A. Eckman,Matthew P. Frosch,Christopher B. Eckman,Rudolph E. Tanzi,Dennis J. Selkoe,Suzanne Y. Guénette +9 more
TL;DR: In vivo findings suggest that IDE hypofunction may underlie or contribute to some forms of AD and DM2 and provide a mechanism for the recently recognized association among hyperinsulinemia, diabetes, and AD.
Journal ArticleDOI
Partial Loss-of-Function Mutations in Insulin-Degrading Enzyme that Induce Diabetes also Impair Degradation of Amyloid β-Protein
Wesley Farris,Stefan Mansourian,Malcolm A. Leissring,Elizabeth A. Eckman,Lars Bertram,Christopher B. Eckman,Rudolph E. Tanzi,Dennis J. Selkoe +7 more
TL;DR: It is concluded that naturally occurring, partial loss-of-function mutations in IDE sufficient to cause DM2 also impair neuronal regulation of Abeta levels, but the brain can apparently compensate for the partial deficit during the life span of the rat.
Journal ArticleDOI
Live discussion: Amyloid-beta degradation: the forgotten half of Alzheimer's disease. 12 September 2002.
Chastity Diane Shaffer Whitaker,Chris Eckman,Claudia G. Almeida,Douglas L. Feinstein,Craig S. Atwood,Elizabeth A. Eckman,Keith A. Crutcher,Lou Hersh,Malcolm Leissring,Matthew J. LaVoie,Nilufer Ertekin-Taner,Paul Shapiro,Reisuke Takahashi,Rina Yamin,Stefan Mansourian,Steve Estus,Sylvain Lesné,Tony Turner,Wes Farris,Gabrielle Stroebel +19 more