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Nilufer Ertekin-Taner
Researcher at Mayo Clinic
Publications - 187
Citations - 9109
Nilufer Ertekin-Taner is an academic researcher from Mayo Clinic. The author has contributed to research in topics: Genome-wide association study & Medicine. The author has an hindex of 43, co-authored 147 publications receiving 6783 citations. Previous affiliations of Nilufer Ertekin-Taner include National Institutes of Health & Scripps Research Institute.
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Journal ArticleDOI
Alzheimer's disease: early alterations in brain DNA methylation at ANK1, BIN1, RHBDF2 and other loci.
Philip L. De Jager,Gyan Srivastava,Katie Lunnon,Jeremy D. Burgess,Leonard C. Schalkwyk,Lei Yu,Matthew L. Eaton,Brendan T. Keenan,Jason Ernst,Cristin McCabe,Anna Tang,Towfique Raj,Joseph M. Replogle,Wendy Brodeur,Stacey Gabriel,High Seng Chai,Curtis S. Younkin,Steven G. Younkin,Fanggeng Zou,Moshe Szyf,Charles B. Epstein,Julie A. Schneider,Bradley E. Bernstein,Alexander Meissner,Nilufer Ertekin-Taner,Lori B. Chibnik,Manolis Kellis,Jonathan Mill,David A. Bennett +28 more
TL;DR: The analyses suggest that DNA methylation changes may have a role in the onset of AD given that they were observed in presymptomatic subjects and that six of the validated genes connect to a known AD susceptibility gene network.
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Large-scale proteomic analysis of Alzheimer’s disease brain and cerebrospinal fluid reveals early changes in energy metabolism associated with microglia and astrocyte activation
Erik C. B. Johnson,Eric B. Dammer,Duc M. Duong,Lingyan Ping,Maotian Zhou,Luming Yin,Lenora Higginbotham,Andrew Guajardo,Bartholomew White,Juan C. Troncoso,Madhav Thambisetty,Thomas J. Montine,Edward B. Lee,John Q. Trojanowski,Thomas G. Beach,Eric M. Reiman,Vahram Haroutunian,Vahram Haroutunian,Minghui Wang,Eric E. Schadt,Bin Zhang,Dennis W. Dickson,Nilufer Ertekin-Taner,Todd E. Golde,Vladislav A. Petyuk,Philip L. De Jager,David A. Bennett,Thomas S. Wingo,Srikant Rangaraju,Ihab Hajjar,Joshua M. Shulman,James J. Lah,Allan I. Levey,Nicholas T. Seyfried +33 more
TL;DR: Large-scale, comprehensive proteomic profiling of Alzheimer’s disease brain and cerebrospinal fluid reveals disease-associated protein coexpression modules and highlights the importance of glia and energy metabolism in disease pathogenesis.
Journal ArticleDOI
Meta-analysis confirms CR1, CLU, and PICALM as Alzheimer disease risk loci and reveals interactions with APOE genotypes.
Gyungah Jun,Adam C. Naj,Gary W. Beecham,Li-San Wang,Jacqueline L. Buros,Paul Gallins,Joseph D. Buxbaum,Nilufer Ertekin-Taner,M. Daniele Fallin,Robert P. Friedland,Rivka Inzelberg,Patricia L. Kramer,Ekaterina Rogaeva,Peter St George-Hyslop,Peter St George-Hyslop,Laura B. Cantwell,Beth A. Dombroski,Andrew J. Saykin,Eric M. Reiman,David A. Bennett,John C. Morris,Kathryn L. Lunetta,Eden R. Martin,Thomas J. Montine,Alison Goate,Deborah Blacker,Debby W. Tsuang,Duane Beekly,L. Adrienne Cupples,Hakon Hakonarson,Walter A. Kukull,Tatiana Foroud,Jonathan L. Haines,Richard Mayeux,Lindsay A. Farrer,Margaret A. Pericak-Vance,Gerard D. Schellenberg +36 more
TL;DR: It is confirmed in a completely independent data set that CR1, CLU, and PICALM are AD susceptibility loci in European ancestry populations.
Journal ArticleDOI
Linkage of Plasma Aβ42 to a Quantitative Locus on Chromosome 10 in Late-Onset Alzheimer's Disease Pedigrees
Nilufer Ertekin-Taner,Neill R. Graff-Radford,Linda H. Younkin,Christopher B. Eckman,Matt Baker,Jennifer Adamson,James Ronald,John Blangero,Mike Hutton,Steven G. Younkin +9 more
TL;DR: In this paper, the authors used plasma Aβ42 as a surrogate trait and performed linkage analysis on extended AD pedigrees identified through a LOAD patient with extremely high Aβ.
Journal ArticleDOI
Variants in the ATP-Binding Cassette Transporter (ABCA7), Apolipoprotein E ε4, and the Risk of Late-Onset Alzheimer Disease in African Americans
Christiane Reitz,Gyungah Jun,Adam C. Naj,Ruchita Rajbhandary,Badri N. Vardarajan,Li-San Wang,Otto Valladares,Chiao-Feng Lin,Eric B. Larson,Eric B. Larson,Neill R. Graff-Radford,Denis A. Evans,Philip L. De Jager,Philip L. De Jager,Paul K. Crane,Joseph D. Buxbaum,Jill R. Murrell,Towfique Raj,Nilufer Ertekin-Taner,Mark W. Logue,Clinton T. Baldwin,Robert C. Green,Lisa L. Barnes,Laura B. Cantwell,M. Daniele Fallin,Rodney C.P. Go,Patrick A. Griffith,Thomas O. Obisesan,Jennifer J. Manly,Kathryn L. Lunetta,M. Ilyas Kamboh,Oscar L. Lopez,David A. Bennett,Hugh C. Hendrie,Hugh C. Hendrie,Kathleen S. Hall,Alison Goate,Goldie S. Byrd,Walter A. Kukull,Tatiana Foroud,Jonathan L. Haines,Lindsay A. Farrer,Margaret A. Pericak-Vance,Gerard D. Schellenberg,Richard Mayeux +44 more
TL;DR: In this meta-analysis of data from African American participants, Alzheimer disease was significantly associated with variants in ABCA7 and with other genes that have been associated with Alzheimer disease in individuals of European ancestry.