T
Thomas J. Rosol
Researcher at Heritage College of Osteopathic Medicine
Publications - 307
Citations - 11727
Thomas J. Rosol is an academic researcher from Heritage College of Osteopathic Medicine. The author has contributed to research in topics: Parathyroid hormone-related protein & Parathyroid hormone. The author has an hindex of 53, co-authored 295 publications receiving 10674 citations. Previous affiliations of Thomas J. Rosol include Ohio University & Ohio State University.
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Journal ArticleDOI
Pten in stromal fibroblasts suppresses mammary epithelial tumours
Anthony J. Trimboli,Carmen Z. Cantemir-Stone,Fu Li,Julie A. Wallace,Anand S. Merchant,Nicholas Creasap,John C. Thompson,Enrico Caserta,Hui Wang,Jean-Leon Chong,Shan Naidu,Guo Wei,Sudarshana M. Sharma,Julie A. Stephens,Soledad Fernandez,Metin N. Gurcan,Michael Weinstein,Sanford H. Barsky,Lisa D. Yee,Thomas J. Rosol,Paul C. Stromberg,Michael L. Robinson,Francois Pepin,Michael Hallett,Morag Park,Michael C. Ostrowski,Gustavo Leone,Gustavo Leone +27 more
TL;DR: The Pten–Ets2 axis is identified as a critical stroma-specific signalling pathway that suppresses mammary epithelial tumours and ameliorated disruption of the tumour microenvironment.
Journal ArticleDOI
Direct evidence for Epithelial-Mesenchymal transitions in breast cancer
Anthony J. Trimboli,Koichi Fukino,Alain de Bruin,Guo Wei,Lei Shen,Stephan M. Tanner,Nicholas Creasap,Thomas J. Rosol,Michael L. Robinson,Charis Eng,Michael C. Ostrowski,Gustavo Leone +11 more
TL;DR: Using three different oncogene-driven mouse mammary tumor models and cell-fate mapping strategies, in vivo evidence for the existence of EMT in breast cancer is shown and it is suggested that its development is favored by myc-initiated events.
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The role of Dickkopf-1 in bone development, homeostasis, and disease
Joseph J. Pinzone,Brett Hall,Nanda K. Thudi,Martin Vonau,Ya-Wei Qiang,Thomas J. Rosol,John D. Shaughnessy +6 more
TL;DR: Preclinical studies have shown that neutralizing DKK1/Dkk1 and/or enhancing Wnt/beta-catenin signaling may prove effective in treating bone pathologies.
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Extra-embryonic function of Rb is essential for embryonic development and viability.
Lizhao Wu,Alain de Bruin,Harold I. Saavedra,Maja Starovic,Anthony J. Trimboli,Ying Yang,Jana Opavska,Pamela Wilson,John C. Thompson,Michael C. Ostrowski,Thomas J. Rosol,Laura A. Woollett,Michael Weinstein,James C. Cross,Michael L. Robinson,Gustavo Leone +15 more
TL;DR: It is shown that Rb-deficient embryos supplied with a wild-type placenta can be carried to term, but die soon after birth, and a mechanism for the cell autonomous versus non-cell autonomous roles of Rb in development is provided.
Journal ArticleDOI
Animal models of bone metastasis
Thomas J. Rosol,Sarah H. Tannehill-Gregg,Bruce E. LeRoy,Stefanie Mandl,Christopher H. Contag +4 more
TL;DR: Animal models are important tools to investigate the pathogenesis and develop treatment strategies for bone metastases in humans and there are few spontaneous models of bone metastasis despite the fact that rodents and other animals often spontaneously develop cancer.