Susan Hedrick

TL;DR: Fasting hyperglycaemia* is strongly correlated with type II diabetes, so the results suggest that the activation of PGC-1 by CREB in liver contributes importantly to the pathogenesis of this disease.

TL;DR: It is shown that hormonal and energy-sensing pathways converge on the coactivator TORC2 (transducer of regulated CREB activity 2) to modulate glucose output and compounds that enhanceTORC2 phosphorylation may offer therapeutic benefits in this setting.

TL;DR: It is shown that, in the liver, TRB-3 is a target for PPAR-α, a fasting-inducible inhibitor of the serine-threonine kinase Akt/PKB, which indicates a link between nuclear hormone receptor and insulin signaling pathways, and suggest a potential role for TRb-3 inhibitors in the treatment of type 2 diabetes.

TL;DR: A fasting-inducible switch, consisting of the histone acetyltransferase p300 and the nutrient-sensing deacetylase sirtuin 1 (SIRT1), maintains energy balance in mice through the sequential induction of CRTC2 and FOXO1 and illustrates how the exchange of two gluconeogenic regulators during fasting maintainsEnergy balance.

TL;DR: It is shown in mice that insulin inhibits gluconeogenic gene expression during re-feeding by promoting the phosphorylation and ubiquitin-dependent degradation of TORC2.