S
Stéphane Vispé
Researcher at Laval University
Publications - 4
Citations - 163
Stéphane Vispé is an academic researcher from Laval University. The author has contributed to research in topics: DNA clamp & DNA polymerase II. The author has an hindex of 4, co-authored 4 publications receiving 157 citations.
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A cellular defense pathway regulating transcription through poly(ADP-ribosyl)ation in response to DNA damage
TL;DR: It is found that automodification of poly(ADP-ribose) polymerase in response to DNA damage resulted in the up-regulation of transcription, presumably because automodified poly( ADP)-ribose molecules were released from transcripts, thereby relieving the block on transcription.
Journal ArticleDOI
Poly(ADP-ribose) Polymerase-1 Is a Negative Regulator of HIV-1 Transcription through Competitive Binding to TAR RNA with Tat·Positive Transcription Elongation Factor b (p-TEFb) Complex
Marianne Parent,Tetsu M.C. Yung,Ann Rancourt,Erick L.Y. Ho,Stéphane Vispé,Fumihiko Suzuki-Matsuda,Aki Uehara,Tadashi Wada,Hiroshi Handa,Masahiko S. Satoh +9 more
TL;DR: The results suggest that PARP-1 acts as a negative regulator of HIV-1 transcription through competitive binding with Tat or the Tat·P-TEFb complex to TAR RNA.
Journal ArticleDOI
DNA repair patch mediated double-strand DNA break formation in human cells
Stéphane Vispé,Masahiko S. Satoh +1 more
TL;DR: In vitro data demonstrate that double strand DNA breaks are produced through formation of DNA repair patches, referred to as the "DNA repair patch-mediated pathway."
Journal ArticleDOI
Double-strand DNA break formation mediated by flap endonuclease-1.
TL;DR: It is reported that, instead of DNA polymerase δ/ϵ, flap endonuclease-1 (FEN-1), an enzyme involved in base excision repair, is responsible for the formation of double-strand DNA break in the assay.