Journal ArticleDOI
DNA repair patch mediated double-strand DNA break formation in human cells
Stéphane Vispé,Masahiko S. Satoh +1 more
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In vitro data demonstrate that double strand DNA breaks are produced through formation of DNA repair patches, referred to as the "DNA repair patch-mediated pathway."About:
This article is published in Journal of Biological Chemistry.The article was published on 2000-09-01. It has received 29 citations till now. The article focuses on the topics: DNA ligase & DNA clamp.read more
Citations
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Journal ArticleDOI
DNA‐PK autophosphorylation facilitates Artemis endonuclease activity
Aaron A. Goodarzi,Yaping Yu,Enriqueta Riballo,Pauline Douglas,Sarah R. Walker,Ruiqiong Ye,Christine J. Härer,Caterina Marchetti,Nick Morrice,Penny A. Jeggo,Susan P. Lees-Miller +10 more
TL;DR: It is proposed that autophosphorylation triggers conformational changes in DNA‐PK that enhance Artemis cleavage at single‐strand to double‐stranded DNA junctions, providing insight into the mechanism of Artemis mediated DNA end processing.
Journal ArticleDOI
Involvement of Polynucleotide Kinase in a Poly(ADP-ribose) Polymerase-1-dependent DNA Double-strand Breaks Rejoining Pathway
TL;DR: Results reveal functional parallels between the PARP-1 and DNA-PK-dependent end-joining processes and establish that the two strands at the junction can be processed and joined independently, so that one strand can be ligated without a ligatable nick on the other strand at the DSB site.
Journal ArticleDOI
Long‐patch DNA repair synthesis during base excision repair in mammalian cells
TL;DR: An assay using a plasmid containing a single modified base in the transcribed strand of the enhanced green fluorescent protein (EGFP) gene and a stop codon based on a single‐nucleotide mismatch shows the existence of LP‐BER in vivo.
Journal ArticleDOI
Monte Carlo Simulation of Base and Nucleotide Excision Repair of Clustered DNA Damage Sites. I. Model Properties and Predicted Trends
TL;DR: A Monte Carlo excision repair (MCER) model is presented that simulates key steps in the short-patch and long-patch BER pathways and the NER pathway and the quantitative implications of alternative hypotheses regarding the postulated repair mechanisms are investigated through a series of parameter sensitivity studies.
Journal ArticleDOI
Huge differences in cellular radiosensitivity due to only very small variations in double-strand break repair capacity.
TL;DR: The relationship between D SB repair capacity and cellular radiosensitivity appears to be the same for normal and mutated cell lines, and that in both cases huge differences in cellular radios sensitivity result from only a very small variation in DSB repair capacity.
References
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Journal ArticleDOI
Instability and decay of the primary structure of DNA
TL;DR: The spontaneous decay of DNA is likely to be a major factor in mutagenesis, carcinogenesis and ageing, and also sets limits for the recovery of DNA fragments from fossils.
Journal ArticleDOI
Quality control by DNA repair.
Tomas Lindahl,Richard D. Wood +1 more
TL;DR: In some cases, DNA damage is not repaired but is instead bypassed by specialized DNA polymerases, and the integrity of the genetic information is compromised.
Book ChapterDOI
DNA damage produced by ionizing radiation in mammalian cells: identities, mechanisms of formation, and reparability.
TL;DR: It has been concluded that the types and yields of damaged moieties produced in intracellular DNA by low LET ionizing radiation are consistent with the mechanisms of production that involve both OH radical attack and a direct ionization of the macromolecule.
Journal ArticleDOI
Role of poly(ADP-ribose) formation in DNA repair
Masahiko S. Satoh,Tomas Lindahl +1 more
TL;DR: The results indicate that unmodified polymerase molecules bind tightly to DNA strand breaks; auto-poly(ADP-ribosyl)ation of the protein then effects its release and allows access to lesions for DNA repair enzymes.
Related Papers (5)
Repair of DNA double-strand breaks in Escherichia coli, which requires recA function and the presence of a duplicate genome.
Frank Krasin,Franklin Hutchinson +1 more
Single-strand breakage on binding of DNA to cells in the genetic transformation of Diplococcus pneumoniae
Sanford A. Lacks,Bill Greenberg +1 more