S
Stephanie Brown
Researcher at John Innes Centre
Publications - 5
Citations - 486
Stephanie Brown is an academic researcher from John Innes Centre. The author has contributed to research in topics: Tabersonine & Gene. The author has an hindex of 4, co-authored 5 publications receiving 376 citations. Previous affiliations of Stephanie Brown include Norwich University & Norwich Research Park.
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Journal ArticleDOI
De novo production of the plant-derived alkaloid strictosidine in yeast
TL;DR: It is demonstrated how strictosidine can be produced de novo in a Saccharomyces cerevisiae host from 14 known monoterpene indole alkaloid pathway genes, along with an additional seven genes and three gene deletions that enhance secondary metabolism.
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Discovery of a P450-catalyzed step in vindoline biosynthesis: a link between the aspidosperma and eburnamine alkaloids
Franziska Kellner,Fernando Geu-Flores,Nathaniel H. Sherden,Stephanie Brown,Emilien Foureau,Vincent Courdavault,Sarah E. O'Connor +6 more
TL;DR: The discovery of a cytochrome P450 that is required for the biosynthesis of vindoline is reported, providing evidence for the long-standing hypothesis that the aspidosperma- and eburnamine-type alkaloids are biosynthetically related.
Journal ArticleDOI
Halogenase Engineering for the Generation of New Natural Product Analogues.
TL;DR: The potential and limitations of using halogenases as biocatalysts are discussed, including recent advances in engineering halogenase to generate halogenated natural product analogues.
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Two Tabersonine 6,7-Epoxidases Initiate Lochnericine-Derived Alkaloid Biosynthesis in Catharanthus roseus
Inês Carqueijeiro,Stephanie Brown,Khoa Chung,Thu-Thuy T. Dang,Manish Walia,Sébastien Besseau,Thomas Dugé de Bernonville,Audrey Oudin,Arnaud Lanoue,Kévin Billet,Thibaut Munsch,Konstantinos Koudounas,Céline Melin,Charlotte Godon,Bienvenue Razafimandimby,Johan-Owen De Craene,Gaëlle Glévarec,Jillian Marc,Nathalie Giglioli-Guivarc’h,Marc Clastre,Benoit St-Pierre,Nicolas Papon,Rodrigo B. Andrade,Sarah E. O'Connor,Vincent Courdavault +24 more
TL;DR: The results suggest that TEX1 and TEX2 originated from a gene duplication event and later acquired divergent, organ-specific regulatory elements for lochnericine biosynthesis throughout the plant, as supported by the presence of lochnersicine in flowers.
Journal ArticleDOI
Halogenase Engineering for the Generation of New Natural Product Analogues
TL;DR: The potential and limitations of using halogenases as biocatalysts are discussed, including recent advances in engineering halogenase to generate halogenated natural product analogues.