T
Thomas Dugé de Bernonville
Researcher at François Rabelais University
Publications - 68
Citations - 1758
Thomas Dugé de Bernonville is an academic researcher from François Rabelais University. The author has contributed to research in topics: Catharanthus roseus & Medicine. The author has an hindex of 22, co-authored 58 publications receiving 1271 citations. Previous affiliations of Thomas Dugé de Bernonville include Institut national de la recherche agronomique & University of Angers.
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Missing enzymes in the biosynthesis of the anticancer drug vinblastine in Madagascar periwinkle
Lorenzo Caputi,Jakob Franke,Scott C. Farrow,Khoa Chung,Richard M. E. Payne,Trinh-Don Nguyen,Thu-Thuy T. Dang,Inês Carqueijeiro,Konstantinos Koudounas,Thomas Dugé de Bernonville,Belinda Ameyaw,D. Marc Jones,Ivo Jose Curcino Vieira,Vincent Courdavault,Sarah E. O'Connor +14 more
TL;DR: Two missing enzymes necessary for vinblastine biosynthesis in this plant are identified: an oxidase and a reductase that isomerize stemmadenine acetate into dihydroprecondylocarpine acetates, which is then deacetoxylated and cyclized to either catharanthine or tabersonine via two hydrolases characterized herein.
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An NPF transporter exports a central monoterpene indole alkaloid intermediate from the vacuole.
Richard M. E. Payne,Deyang Xu,Emilien Foureau,Marta Ines Soares Teto Carqueijeiro,Audrey Oudin,Thomas Dugé de Bernonville,Vlastimil Novak,Meike Burow,Carl-Erik Olsen,D. Marc Jones,Evangelos C. Tatsis,Ali Pendle,Barbara Ann Halkier,Fernando Geu-Flores,Vincent Courdavault,Hussam Hassan Nour-Eldin,Sarah E. O'Connor +16 more
TL;DR: A tonoplast localized nitrate/peptide family (NPF) transporter from Catharanthus roseus is presented that exports strictosidine, the central intermediate of this pathway, into the cytosol from the vacuole.
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A three enzyme system to generate the Strychnos alkaloid scaffold from a central biosynthetic intermediate
Evangelos C. Tatsis,Inês Carqueijeiro,Thomas Dugé de Bernonville,Jakob Franke,Thu-Thuy T. Dang,Audrey Oudin,Arnaud Lanoue,Florent Lafontaine,Anna Stavrinides,Marc Clastre,Vincent Courdavault,Sarah E. O'Connor +11 more
TL;DR: It is shown that the concerted action of two enzymes commonly involved in natural product metabolism—an alcohol dehydrogenase and a cytochrome P450—produces unexpected rearrangements in strictosidine when assayed simultaneously.
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Dihydrochalcones: Implication in resistance to oxidative stress and bioactivities against advanced glycation end-products and vasoconstriction.
Thomas Dugé de Bernonville,Sylvain Guyot,Jean-Pierre Paulin,Matthieu Gaucher,Laurent Loufrani,Daniel Henrion,Séverine Derbré,David Guilet,Pascal Richomme,James F. Dat,Marie-Noëlle Brisset +10 more
TL;DR: The results strongly argue for the bioactivity of dihydrochalcones as functional antioxidants in the resistance of Malus leaves to oxidative stress and demonstrate for the first time that sieboldin is a powerful multipotent antioxidant, effective in preventing physiopathological processes.
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Phytochemical genomics of the Madagascar periwinkle: Unravelling the last twists of the alkaloid engine.
Thomas Dugé de Bernonville,Marc Clastre,Sébastien Besseau,Audrey Oudin,Vincent Burlat,Gaëlle Glévarec,Arnaud Lanoue,Nicolas Papon,Nathalie Giglioli-Guivarc’h,Benoit St-Pierre,Vincent Courdavault +10 more
TL;DR: Tissue specific library screening, orthology comparison in species with or without MIA-biochemical engines, clustering of gene expression profiles together with various functional validation strategies, largely contributed to enrich the toolbox for plant synthetic biology and metabolic engineering of MIA biosynthesis.