S
Stéphanie Louis
Researcher at French Institute of Health and Medical Research
Publications - 12
Citations - 1216
Stéphanie Louis is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: IL-2 receptor & Antigen. The author has an hindex of 10, co-authored 12 publications receiving 1176 citations. Previous affiliations of Stéphanie Louis include University of Nantes & Centre national de la recherche scientifique.
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Journal ArticleDOI
Identification of a peripheral blood transcriptional biomarker panel associated with operational renal allograft tolerance
Sophie Brouard,Elaine Mansfield,Christophe Braud,Li Li,Magali Giral,Szu-Chuan Hsieh,Dominique Baeten,Meixia Zhang,Joanna Ashton-Chess,Cécile Braudeau,Frank Hsieh,Alexandre Dupont,A. Pallier,Anne Moreau,Stéphanie Louis,Catherine Ruiz,Oscar Salvatierra,Jean-Paul Soulillou,Minnie M. Sarwal +18 more
TL;DR: This study identifies in the blood of kidney recipients a set of genes associated with operational tolerance that may have utility as a minimally invasive monitoring tool for guiding IS titration.
Journal ArticleDOI
Contrasting CD25hiCD4+T cells/FOXP3 patterns in chronic rejection and operational drug-free tolerance.
Stéphanie Louis,Cécile Braudeau,Magali Giral,Alexandre Dupont,Frédérique Moizant,Nelly Robillard,Anne Moreau,Jean-Paul Soulillou,Sophie Brouard +8 more
TL;DR: Data show that chronic rejection is associated with a decrease in CD25hiCD4+T cells and FOXP3 transcripts, suggesting that clinically “operational tolerance” may be due to a maintained phenomenon of natural tolerance that is lacking in patients with chronic rejection.
Journal ArticleDOI
Variation in numbers of CD4+CD25highFOXP3+ T cells with normal immuno-regulatory properties in long-term graft outcome.
Cécile Braudeau,Maud Racapé,Magali Giral,Stéphanie Louis,Anne Moreau,Laureline Berthelot,Michèle Heslan,Joanna Ashton-Chess,Jean-Paul Soulillou,Sophie Brouard +9 more
TL;DR: It is shown that CR is associated with a decreased number of CD4+CD25highFOXP3+T cells with normal regulatory profile, whereas graft acceptance isassociated with CD4-CD25 highFOXP 3+T cell numbers similar to HVs, which suggest that Treg numbers, rather than their intrinsic suppressive capacity, may contribute to determining the long‐term fate of renal transplants.
Journal ArticleDOI
Phenotypically and Functionally Distinct CD8+ Lymphocyte Populations in Long-Term Drug-Free Tolerance and Chronic Rejection in Human Kidney Graft Recipients
Dominique Baeten,Stéphanie Louis,Christophe Braud,Cécile Braudeau,Caroline Ballet,Frédéric Moizant,A. Pallier,Magali Giral,Sophie Brouard,Jean-Paul Soulillou +9 more
TL;DR: Data show a strong cytotoxicity-associated CD8+CD28- signature in CR and suggest a suppression of pathologic cytot toxicity in DF-Tol, suggesting patients who are at risk for CR when immunosuppression is tapered are identified.
Journal ArticleDOI
Operationally tolerant and minimally immunosuppressed kidney recipients display strongly altered blood T-cell clonal regulation.
Sophie Brouard,Alexandre Dupont,Magali Giral,Stéphanie Louis,David Lair,Cécile Braudeau,Nicolas Degauque,Frédérique Moizant,Annaïck Pallier,Catherine Ruiz,Marina Guillet,David Laplaud,Jean-Paul Soulillou +12 more
TL;DR: Comparison of T‐cell selection in drug‐free operationally tolerant kidney recipients (or with minimal immunosuppression), recipients with stable graft function, chronic rejection and healthy individuals is reported.