Stephanie M. Linker

TL;DR: This study applies parallel DNA methylation and transcriptome sequencing to differentiating human induced pluripotent stem cells to characterize splicing variation (exon skipping) and its determinants and reveals a previously underappreciated link betweenDNA methylation variation and splicing.

TL;DR: Real-time metabolomics and single-cell imaging are used to demonstrate that the internal storage polymer glycogen plays a crucial role in the dynamic physiological adaptation of Escherichia coli to fluctuating nutrients following carbon starvation, highlighting an underappreciated role of glycogen in rapidly providing carbon and energy in changing environments, thereby increasing survival and competition capabilities under fluctuations and nutrient-poor conditions.

TL;DR: It is shown that membrane-spanning carbon nanotubes (CNTs) can trigger spontaneous fusion of small lipid vesicles, and the distinct mechanism of CNT-mediated membrane fusion may be transferable, providing guidance in the development of fusion agents, e.g., for the targeted delivery of drugs or nucleic acids.

TL;DR: This study yields new insights into alternative splicing at the single-cell level and reveals a previously underappreciated link between DNA methylation variation and splicing.

TL;DR: A computational method is introduced which is able to reliably predict binding sites and binding modes of fragment-like small molecules using solely the structure of the apo-protein and the ligand's chemical structure as input information.