S
Stephanie S. Watowich
Researcher at University of Texas MD Anderson Cancer Center
Publications - 129
Citations - 16730
Stephanie S. Watowich is an academic researcher from University of Texas MD Anderson Cancer Center. The author has contributed to research in topics: Signal transduction & Cellular differentiation. The author has an hindex of 48, co-authored 113 publications receiving 14947 citations. Previous affiliations of Stephanie S. Watowich include University of Texas Health Science Center at Houston & Northwestern University.
Papers
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Journal ArticleDOI
T Helper 17 Lineage Differentiation Is Programmed by Orphan Nuclear Receptors RORα and RORγ
Xuexian O. Yang,Bhanu P. Pappu,Roza Nurieva,Askar M. Akimzhanov,Hong Soon Kang,Yeonseok Chung,Li Ma,Bhavin Shah,Athanasia D. Panopoulos,Kimberly S. Schluns,Stephanie S. Watowich,Qiang Tian,Anton M. Jetten,Chen Dong +13 more
TL;DR: Th17 differentiation is directed by two lineage-specific nuclear receptors, ROR alpha and ROR gamma, and is induced by transforming growth factor-beta and interleukin-6 (IL-6), which is dependent on signal transducer and activator of transcription 3.
Journal ArticleDOI
Essential autocrine regulation by IL-21 in the generation of inflammatory T cells
Roza Nurieva,Xuexian O. Yang,Gustavo J. Martinez,Yongliang Zhang,Athanasia D. Panopoulos,Li Ma,Kimberly S. Schluns,Qiang Tian,Stephanie S. Watowich,Anton M. Jetten,Chen Dong +10 more
TL;DR: IL-21 is shown to be an autocrine cytokine that is sufficient and necessary for TH17 differentiation, and serves as a target for treating inflammatory diseases.
Journal ArticleDOI
Stat3 regulates cytokine-mediated generation of inflammatory helper t cells
Xuexian O. Yang,Athanasia D. Panopoulos,Roza Nurieva,Seon Hee Chang,Demin Wang,Stephanie S. Watowich,Chen Dong +6 more
TL;DR: A pathway whereby cytokines regulate THi differentiation through a selective STAT transcription factor that functions to regulate lineage-specific gene expression is demonstrated.
Journal ArticleDOI
Generation of T Follicular Helper Cells Is Mediated by Interleukin-21 but Independent of T Helper 1, 2, or 17 Cell Lineages
Roza Nurieva,Yeonseok Chung,Daehee Hwang,Xuexian O. Yang,Hong Soon Kang,Li Ma,Yi Hong Wang,Stephanie S. Watowich,Anton M. Jetten,Qiang Tian,Chen Dong +10 more
TL;DR: It is shown that Tfh cells had a distinct gene expression profile and developed in vivo independently of the Th1 or Th2 cell lineages and was dependent on interleukin-21 (IL-21), IL-6, and signal transducer and activator of transcription 3 (STAT3) in vivo.
Journal ArticleDOI
Critical Regulation of Early Th17 Cell Differentiation by Interleukin-1 Signaling
Yeonseok Chung,Seon Hee Chang,Gustavo J. Martinez,Xuexian O. Yang,Roza Nurieva,Hong Soon Kang,Li Ma,Stephanie S. Watowich,Anton M. Jetten,Qiang Tian,Chen Dong +10 more
TL;DR: It is shown that interleukin-1 (IL-1) signaling on T cells is critically required for the early programming of Th 17 cell lineage and Th17 cell-mediated autoimmunity and this pathway may serve as a unique target for Th17cell-mediated immunopathology.