S
Stephen D. Smith
Researcher at Brigham and Women's Hospital
Publications - 2
Citations - 1848
Stephen D. Smith is an academic researcher from Brigham and Women's Hospital. The author has contributed to research in topics: Gene & Chromosomal translocation. The author has an hindex of 2, co-authored 2 publications receiving 1812 citations.
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TAN-1, the human homolog of the Drosophila notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms.
Leif W. Ellisen,Jeffrey Bird,Daniel C. West,A. Lee Soreng,Thomas C. Reynolds,Stephen D. Smith,Jeffrey Sklar +6 more
TL;DR: It is shown that the locus on chromosome 9 contains a gene highly homologous to the Drosophila gene Notch, which may be important for normal lymphocyte function and that alteration of TAN-1 may play a role in the pathogenesis of some T cell neoplasms.
Journal ArticleDOI
Lymphocytic progenitor cell origin and clonal evolution of human B- lineage acute lymphoblastic leukemia
TL;DR: The hypothesis that some ALLs arise from a lymphoid progenitor cell at a stage of lymphocyte development before the onset of IgH gene rearrangement is supported.