Stephen G. Taylor

TL;DR: One compound, trans-3,4-dihydro-2,2-dimethyl-4-(2-oxopiperidin-1-yl)-7-(trifluor omethyl)-2H- 1-benzopyran-3-ol (24), was resolved into its two enantiomers and the activity was shown to reside essentially in the (+)-isomer, adding further support to the suggestion that the smooth muscle receptor for these potassium channel

TL;DR: 6-cyano-2,2-dimethyl-N-methyl-N -methyl-2H-1-benzopyran-4-thiocarboxamide was shown to be a potent potassium channel activator in vitro and to provide prolonged protection to guinea pigs from the respiratory effects of inhaled histamine.

TL;DR: One compound in particular, 1,1-dimethyl-5-nitro-3-(2-pyridon-1-yl)indan-2-ol, was identified as a potent relaxant of airways smooth muscle in vitro and was found to significantly inhibit histamine-induced dyspnoea in conscious guinea pigs when given orally 30-45 min prior to challenge.

TL;DR: It is proposed that cromakalim is opening two populations of potassium channel in guinea pig tracheal smooth muscle, one of which is susceptible to blockade by Rb+ and one ofWhich is not.

TL;DR: A series of 4-amido-3,4-dihydro-2H-1-benzopyran-3-ols and 4amido 2H 1-Benzoprin-3ol derivatives have been evaluated for their relaxant activity in guinea pig isolated tracheal spirals as discussed by the authors.