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Stephen H. Prior
Researcher at University of Portsmouth
Publications - 2
Citations - 270
Stephen H. Prior is an academic researcher from University of Portsmouth. The author has contributed to research in topics: Protein structure & Binding site. The author has an hindex of 2, co-authored 2 publications receiving 246 citations.
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Journal ArticleDOI
Design and structure of stapled peptides binding to estrogen receptors.
Chris Phillips,Lee R. Roberts,Markus Schade,Richard Bazin,Andrew F. Bent,Nichola L. Davies,Robert Moore,Andrew Pannifer,Andrew R. Pickford,Stephen H. Prior,Christopher M. Read,Andrew D. Scott,David G. Brown,Bin Xu,Stephen L. Irving +14 more
TL;DR: This work describes the design of a series of novel stapled peptides that bind the coactivator peptide site of estrogen receptors and demonstrates that all-hydrocarbon staples modulate molecular recognition events.
Journal ArticleDOI
The Interface between Catalytic and Hemopexin Domains in Matrix Metalloproteinase-1 Conceals a Collagen Binding Exosite
Laurence H. Arnold,Louise E. Butt,Stephen H. Prior,Christopher M. Read,Gregg B. Fields,Andrew R. Pickford +5 more
TL;DR: Biophysical methods use biophysical methods to study the complex formed between the MMP-1 HPX domain and a synthetic triple helical peptide (THP) that encompasses the M MP-1 cleavage site of the collagen α1(I) chain to find a balanced equilibrium between these compact and dislocated states.