S
Stephen J. Kron
Researcher at University of Chicago
Publications - 191
Citations - 11061
Stephen J. Kron is an academic researcher from University of Chicago. The author has contributed to research in topics: DNA damage & DNA repair. The author has an hindex of 50, co-authored 181 publications receiving 10189 citations. Previous affiliations of Stephen J. Kron include Massachusetts Institute of Technology & Wisconsin Alumni Research Foundation.
Papers
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Journal ArticleDOI
Fluorescent actin filaments move on myosin fixed to a glass surface
Stephen J. Kron,James A. Spudich +1 more
TL;DR: Evidence was obtained to suggest that movement of actin over myosin requires at most the number of heads in a single thick filament, and this system provides a practical, quantitativeMyosin-movement assay with purified proteins.
Journal ArticleDOI
Peptide chips for the quantitative evaluation of protein kinase activity.
TL;DR: This paper describes a peptide chip that overcomes limitations, and demonstrates its utility in activity assays of the nonreceptor tyrosine kinase c-Src, and quantitatively evaluated three inhibitors of the enzyme in an array format on a single, homogeneous substrate.
Journal ArticleDOI
Binding of Chromatin-Modifying Activities to Phosphorylated Histone H2A at DNA Damage Sites
Jessica A. Downs,Stéphane Allard,Olivier Jobin-Robitaille,Ali Javaheri,Andréanne Auger,Nathalie Bouchard,Stephen J. Kron,Stephen P. Jackson,Jacques Côté +8 more
TL;DR: It is shown that phosphorylation occurs rapidly over a large region around DNA double-strand breaks (DSBs) and leads to stepwise chromatin reconfiguration, allowing efficient DNA repair.
Journal ArticleDOI
Myosin subfragment-1 is sufficient to move actin filaments in vitro.
Yoko Y. Toyoshima,Stephen J. Kron,Elizabeth M. McNally,Kenneth R. Niebling,Chikashi Toyoshima,James A. Spudich +5 more
TL;DR: That S1 is sufficient to cause sliding movement of actin filaments in vitro gives strong support to models of contraction that place the site of active movement in muscle within the myosin head.
Patent
Method for performing amplification of nucleic acid with two primers bound to a single solid support
TL;DR: In this paper, the authors present methods and apparatus for performing nucleic acid hybridization and amplification processes on a support, which are useful for synthesizing nucleic acids and detecting target nucleic acyclic acid for diagnostics and therapeutics.