Stephen J. Tucker

TL;DR: The results suggest that SUR1 may possess separate high-affinity binding sites for sulfonylurea and Benzamido groups, and drugs that bind to the common benzamido site have the potential to cause side effects on the heart.

TL;DR: It is shown here that mutant ATP-sensitive K+ channels can be used to measure [ATP]sm by comparing the increase in current amplitude on patch excision with the ATP dose-response curve and that there is no gradient between bulk cytosolic and submembrane ATP.

TL;DR: Crystal structures of the human TREK-2 channel are presented in two conformations and in complex with norfluoxetine, the active metabolite of fluoxettine (Prozac) and a state-dependent blocker of TREK channels, providing an explanation for TREK channel mechanosensitivity, regulation by diverse stimuli, and possible off-target effects of the serotonin reuptake inhibitor Prozac.

TL;DR: It is found that Kir6.2 is highly selective for ATP, and that both the adenine moiety and the β‐phosphate contribute to specificity, and several mutations that significantly reduce ATP inhibition are identified.

TL;DR: Computational, structural, and functional studies now indicate that biological ion channels may also exploit hydrophobic gating to regulate ion flow within their pores.