S
Stephen M. Boyle
Researcher at Virginia–Maryland Regional College of Veterinary Medicine
Publications - 100
Citations - 4850
Stephen M. Boyle is an academic researcher from Virginia–Maryland Regional College of Veterinary Medicine. The author has contributed to research in topics: Brucella melitensis & Brucella. The author has an hindex of 37, co-authored 100 publications receiving 4528 citations. Previous affiliations of Stephen M. Boyle include Virginia Tech.
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Journal ArticleDOI
Brucellosis: A re-emerging zoonosis
TL;DR: Brucellosis, especially caused by Brucella melitensis, remains one of the most common zoonotic diseases worldwide with more than 500,000 human cases reported annually.
Journal ArticleDOI
The Brucella suis genome reveals fundamental similarities between animal and plant pathogens and symbionts
Ian T. Paulsen,Ian T. Paulsen,Rekha Seshadri,Karen E. Nelson,Jonathan A. Eisen,Jonathan A. Eisen,John F. Heidelberg,Timothy D. Read,Robert J. Dodson,Lowell Umayam,Lauren M. Brinkac,Maureen J. Beanan,Sean C. Daugherty,Robert T. DeBoy,A. Scott Durkin,James F. Kolonay,Ramana Madupu,William C. Nelson,Bola Ayodeji,Margaret Kraul,Jyoti Shetty,Joel A. Malek,Susan Van Aken,Steven B. Riedmuller,Hervé Tettelin,Steven R. Gill,Owen White,Steven L. Salzberg,Steven L. Salzberg,David L. Hoover,Luther E. Lindler,Shirley M. Halling,Stephen M. Boyle,Claire M. Fraser,Claire M. Fraser +34 more
TL;DR: Comparison of B. suis with Brucella melitensis has defined a finite set of differences that could be responsible for the differences in virulence and host preference between these organisms, and indicates that phage have played a significant role in their divergence.
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Biological properties of RB51; a stable rough strain of Brucella abortus.
Gerhardt G. Schurig,R.Martin Roop,Tamishraha Bagchi,Stephen M. Boyle,D. Buhrman,Nammalwar Sriranganathan +5 more
TL;DR: A rifampin-resistant mutant of Brucella abortus, designated RB51, was derived by repeated passage of strain 2308 on Trypticase soy supplemented with 1.5% agar and varying concentrations rifampsin or penicillin, indicating a rough type colonial morphology for this strain.
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Identification of an IS711 element interrupting the wboA gene of Brucella abortus vaccine strain RB51 and a PCR assay to distinguish strain RB51 from other Brucella species and strains.
Ramesh Vemulapalli,John R. McQuiston,Gerhardt G. Schurig,Nammalwar Sriranganathan,Shirley M. Halling,Stephen M. Boyle +5 more
TL;DR: It is demonstrated that thewboA gene encoding a glycosyltransferase, an enzyme essential for the synthesis of O antigen, is disrupted by an IS711 element in B. abortus vaccine strain RB51, a natural stable attenuated rough mutant derived from the virulent strain 2308.
Journal ArticleDOI
A History of the Development of Brucella Vaccines
Eric Daniel Avila-Calderón,Ahidé López-Merino,Nammalwar Sriranganathan,Stephen M. Boyle,Araceli Contreras-Rodríguez +4 more
TL;DR: The aim of this paper is to review and discuss the importance of methodologies used to develop Brucella vaccines in pursuing this challenge of finding an effective human vaccine.