S
Stephen M. Cifuni
Researcher at Boston Children's Hospital
Publications - 25
Citations - 2565
Stephen M. Cifuni is an academic researcher from Boston Children's Hospital. The author has contributed to research in topics: Platelet & Inflammation. The author has an hindex of 16, co-authored 25 publications receiving 2177 citations. Previous affiliations of Stephen M. Cifuni include Harvard University.
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Journal ArticleDOI
P-selectin promotes neutrophil extracellular trap formation in mice
Julia Etulain,Julia Etulain,Kimberly Martinod,Kimberly Martinod,Siu Ling Wong,Stephen M. Cifuni,Mirta Schattner,Denisa D. Wagner +7 more
TL;DR: P-selectin, cellular or soluble, through binding to PSGL-1, promotes NETosis, suggesting that this pathway is a potential therapeutic target for NET-related diseases.
Journal ArticleDOI
Inflammation induces hemorrhage in thrombocytopenia
Tobias Goerge,Benoît Ho-Tin-Noé,Carla Carbo,Charaf Benarafa,Eileen Remold-O'Donnell,Bing-Qiao Zhao,Stephen M. Cifuni,Denisa D. Wagner +7 more
TL;DR: It is proposed that inflammation may cause life-threatening hemorrhage during thrombocytopenia, with a continuous need for platelets to maintain vascular integrity in inflamed microcirculation.
Journal ArticleDOI
Extracellular DNA traps are associated with the pathogenesis of TRALI in humans and mice.
Grace M. Thomas,Grace M. Thomas,Carla Carbo,Carla Carbo,Brian R. Curtis,Kimberly Martinod,Kimberly Martinod,Irina B. Mazo,Irina B. Mazo,Daphne Schatzberg,Stephen M. Cifuni,Tobias A. Fuchs,Tobias A. Fuchs,Ulrich H. von Andrian,Ulrich H. von Andrian,John H. Hartwig,Richard H. Aster,Denisa D. Wagner,Denisa D. Wagner +18 more
TL;DR: It is suggested that NETs form in the lungs duringTRALI, contribute to the disease process, and thus could be targeted to prevent or treat TRALI.
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Platelet serotonin promotes the recruitment of neutrophils to sites of acute inflammation in mice
Daniel Duerschmied,Georgette L. Suidan,Georgette L. Suidan,Melanie Demers,Melanie Demers,Nadine Herr,Carla Carbo,Carla Carbo,Alexander Brill,Alexander Brill,Stephen M. Cifuni,Maximilian Mauler,Sanja Cicko,Michael Bader,Marco Idzko,Christoph Bode,Denisa D. Wagner,Denisa D. Wagner +17 more
TL;DR: Platelet serotonin promotes the recruitment of neutrophils in acute inflammation, supporting an important role for platelet serotonin in innate immunity.
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The role of platelet adhesion receptor GPIbα far exceeds that of its main ligand, von Willebrand factor, in arterial thrombosis
Wolfgang Bergmeier,Crystal L. Piffath,Tobias Goerge,Stephen M. Cifuni,Zaverio M. Ruggeri,Jerry Ware,Denisa D. Wagner +6 more
TL;DR: In vivo evidence is provided that GPIbα absolutely is required for recruitment of platelets to both exposed subendothelium and thrombi under arterial flow conditions and contributes to arterial thrombosis by important adhesion mechanisms independent of the binding to VWF.