M
Maximilian Mauler
Researcher at University of Freiburg
Publications - 29
Citations - 973
Maximilian Mauler is an academic researcher from University of Freiburg. The author has contributed to research in topics: Inflammation & Platelet. The author has an hindex of 13, co-authored 28 publications receiving 699 citations. Previous affiliations of Maximilian Mauler include University of Freiburg Faculty of Biology.
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Journal ArticleDOI
Platelet serotonin promotes the recruitment of neutrophils to sites of acute inflammation in mice
Daniel Duerschmied,Georgette L. Suidan,Georgette L. Suidan,Melanie Demers,Melanie Demers,Nadine Herr,Carla Carbo,Carla Carbo,Alexander Brill,Alexander Brill,Stephen M. Cifuni,Maximilian Mauler,Sanja Cicko,Michael Bader,Marco Idzko,Christoph Bode,Denisa D. Wagner,Denisa D. Wagner +17 more
TL;DR: Platelet serotonin promotes the recruitment of neutrophils in acute inflammation, supporting an important role for platelet serotonin in innate immunity.
Journal ArticleDOI
Peptidylarginine deiminase 4 promotes age-related organ fibrosis
Kimberly Martinod,Kimberly Martinod,Thilo Witsch,Thilo Witsch,Luise Erpenbeck,Luise Erpenbeck,Alexander Savchenko,Alexander Savchenko,Hideki Hayashi,Hideki Hayashi,Deya Cherpokova,Deya Cherpokova,Maureen Gallant,Maximilian Mauler,Stephen M. Cifuni,Denisa D. Wagner,Denisa D. Wagner +16 more
TL;DR: It is concluded that PAD4 regulates age-related organ fibrosis and dysfunction and proposes a role for NETs in cardiac fibrosis, and DNase 1 was given to assess the effects of extracellular chromatin.
Journal ArticleDOI
Platelet Serotonin Aggravates Myocardial Ischemia/Reperfusion Injury via Neutrophil Degranulation
Maximilian Mauler,Nadine Herr,Claudia Schoenichen,Thilo Witsch,Timoteo Marchini,Carmen Härdtner,Christoph Koentges,Korbinian Kienle,Korbinian Kienle,Véronique Ollivier,Véronique Ollivier,Maximilian Schell,Ludwig Dorner,Christopher Wippel,Daniela Stallmann,Claus Normann,Claus Normann,Heiko Bugger,Paul Walther,Dennis Wolf,Dennis Wolf,Ingo Ahrens,Tim Lämmermann,Benoît Ho-Tin-Noé,Benoît Ho-Tin-Noé,Klaus Ley,Christoph Bode,Ingo Hilgendorf,Daniel Duerschmied +28 more
TL;DR: Serotonin is identified as a potent therapeutic target in neutrophil-dependent thromboinflammation during myocardial reperfusion injury and patients with depression using serotonin reuptake inhibition are presented with suppressed levels of CD11b surface expression on neutrophils and lower myeloperoxidase levels in blood.
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A ligand-specific blockade of the integrin Mac-1 selectively targets pathologic inflammation while maintaining protective host-defense
Dennis Wolf,Dennis Wolf,Nathaly Anto-Michel,Hermann Blankenbach,Ansgar Wiedemann,Konrad Buscher,Jan David Hohmann,Bock Lim,Marina Bäuml,Alex Marki,Maximilian Mauler,Daniel Duerschmied,Zhichao Fan,Holger Winkels,Daniel Sidler,Philipp Diehl,Dirk M. Zajonc,Ingo Hilgendorf,Peter Stachon,Timoteo Marchini,Florian Willecke,Maximilian Schell,Maximilian Schell,Björn Sommer,Constantin von zur Mühlen,Jochen Reinöhl,Teresa Gerhardt,Edward F. Plow,Valentin P. Yakubenko,Peter Libby,Christoph Bode,Klaus Ley,Karlheinz Peter,Andreas Zirlik +33 more
TL;DR: An anti-Mac1 antibody is reported that blocks its interaction with pro-inflammatory ligand CD40L but not other ligands, and it can protect against sepsis in mice and open a path for a new field of ligand-targeted anti-integrin therapy to prevent inflammatory conditions.
Journal ArticleDOI
Functional Relevance of the Anaphylatoxin Receptor C3aR for Platelet Function and Arterial Thrombus Formation Marks an Intersection Point Between Innate Immunity and Thrombosis
Reinhard Sauter,Manuela Sauter,Edimara S. Reis,Frederic Emschermann,Henry Nording,Sonja Ebenhöch,Peter Kraft,Patrick Münzer,Maximilian Mauler,Johannes Rheinlaender,Johannes Madlung,Frank Edlich,Tilman E. Schäffer,Sven G. Meuth,Daniel Duerschmied,Tobias Geisler,Oliver Borst,Meinrad Gawaz,Christoph Kleinschnitz,John D. Lambris,Harald F. Langer +20 more
TL;DR: It is demonstrated that the C3a/C3aR axis on platelets regulates distinct steps of thrombus formation such as platelet adhesion, spreading, and Ca2+ influx, and the observed effects on thrombosis, myocardial infarction, and stroke were specifically caused by platelet C3 aR.