S
Stephen M. Husbands
Researcher at University of Bath
Publications - 183
Citations - 4456
Stephen M. Husbands is an academic researcher from University of Bath. The author has contributed to research in topics: Opioid receptor & Opioid. The author has an hindex of 33, co-authored 178 publications receiving 3854 citations. Previous affiliations of Stephen M. Husbands include National Institutes of Health & Torrey Pines Institute for Molecular Studies.
Papers
More filters
Journal ArticleDOI
Structural insights into µ-opioid receptor activation
Weijiao Huang,Aashish Manglik,AJ Venkatakrishnan,Toon Laeremans,Evan N. Feinberg,Adrian L. Sanborn,Hideaki E. Kato,Kathryn E. Livingston,Thor S. Thorsen,Ralf C. Kling,Sébastien Granier,Peter Gmeiner,Stephen M. Husbands,John R. Traynor,William I. Weis,Jan Steyaert,Ron O. Dror,Brian K. Kobilka +17 more
TL;DR: A 2.1 Å X-ray crystal structure of the murine μOR bound to the morphinan agonist BU72 and a G protein mimetic camelid antibody fragment is reported, revealing an extensive polar network between the ligand-binding pocket and the cytoplasmic domains appears to play a similar role in signal propagation for all three G-protein-coupled receptors.
Journal ArticleDOI
The novel μ-opioid receptor agonist PZM21 depresses respiration and induces tolerance to antinociception
Rob Hill,Alex Disney,Alex E Conibear,Katy J. Sutcliffe,William L. Dewey,Stephen M. Husbands,Christopher P Bailey,Eamonn Kelly,Graeme Henderson +8 more
TL;DR: The signalling profile of PZM21 is re‐examined and its ability to depress respiration is examined, finding it devoid of the respiratory depressant effects characteristic of classical μ receptor ligands such as morphine.
Journal ArticleDOI
Yawning and hypothermia in rats: effects of dopamine D3 and D2 agonists and antagonists
Gregory T. Collins,Amy Hauck Newman,Peter Grundt,Kenner C. Rice,Stephen M. Husbands,Cédric Chauvignac,Jianyong Chen,Shaomeng Wang,James H. Woods +8 more
TL;DR: D3 and D2 receptors have specific roles in the mediation of yawning and hypothermia, respectively, and the analysis of these effects allow inferences to be made regarding the selectivity of D2/D3 agonists and antagonists with respect to their actions at D2 and D3 receptors.
Journal ArticleDOI
β-carboline binding to imidazoline receptors
Stephen M. Husbands,Richard A. Glennon,Stephane Gorgerat,Rhianon Gough,Robin J. Tyacke,John Crosby,David J. Nutt,John W. Lewis,Alan L. Hudson +8 more
TL;DR: It is apparent from this study that many of the β-carbolines prepared display substantially higher affinity for the imidazoline sites and this finding, and those showing modulation of some behavioural effects of morphine by I2-ligands, suggests that imidrazoline sites may be interesting new targets in drug abuse research.