S
Stephen M. Kwong
Researcher at University of Sydney
Publications - 31
Citations - 1944
Stephen M. Kwong is an academic researcher from University of Sydney. The author has contributed to research in topics: Plasmid & Mobile genetic elements. The author has an hindex of 19, co-authored 28 publications receiving 1266 citations. Previous affiliations of Stephen M. Kwong include University of Texas MD Anderson Cancer Center & National University of Singapore.
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Journal ArticleDOI
Mobile Genetic Elements Associated with Antimicrobial Resistance
TL;DR: The characteristics of the major types of mobile genetic elements involved in acquisition and spread of antibiotic resistance in both Gram-negative and Gram-positive bacteria are outlined, focusing on the so-called ESKAPEE group of organisms, which have become the most problematic hospital pathogens.
Journal ArticleDOI
An updated view of plasmid conjugation and mobilization in Staphylococcus.
Joshua P. Ramsay,Stephen M. Kwong,Riley J. T. Murphy,Karina Yui Eto,Karina J. Price,Quang T. Nguyen,Frances G. O'Brien,Warren B. Grubb,Geoffrey W. Coombs,Neville Firth +9 more
TL;DR: It is suggested that a greater research focus on the molecular biology of conjugation is essential if the accretion and dissemination of antimicrobial-resistance genes in the human and animal pathogen Staphylococcus aureus is to be recognized from increasingly in silico analyses.
Journal ArticleDOI
The RepA_N replicons of Gram-positive bacteria: a family of broadly distributed but narrow host range plasmids.
TL;DR: Comparison of stability determinants associated with the RepA_N replicons suggests that they have a modular evolution as has been observed in other plasmid families.
Journal ArticleDOI
Staphylococcus aureus multiresistance plasmid pSK41: analysis of the replication region, initiator protein binding and antisense RNA regulation.
TL;DR: The replication region of pSK41 encodes a protein product, Rep, which was shown to be essential for replication; mutations that truncated Rep could be complemented in trans and transcriptional start points for both RNAI and the rep‐mRNA were defined.
Journal ArticleDOI
Molecular basis of antibiotic multiresistance transfer in Staphylococcus aureus
Jonathan S. Edwards,Laurie Betts,Monica L. Frazier,Rebecca M. Pollet,Stephen M. Kwong,William G. Walton,W. Keith Ballentine,Julianne J. Huang,Sohrab Habibi,Mark Del Campo,Jordan L. Meier,Peter B. Dervan,Neville Firth,Matthew R. Redinbo +13 more
TL;DR: The structural basis for antibiotic multiresistance acquisition by S. aureus is revealed and novel strategies for therapeutic intervention are suggested, including DNA minor groove-targeted polyamide that inhibits NES with low micromolar efficacy.