S
Stephen Nesnow
Researcher at United States Environmental Protection Agency
Publications - 178
Citations - 4669
Stephen Nesnow is an academic researcher from United States Environmental Protection Agency. The author has contributed to research in topics: Benzo(a)pyrene & DNA adduct. The author has an hindex of 37, co-authored 178 publications receiving 4511 citations. Previous affiliations of Stephen Nesnow include Research Triangle Park & University of Texas MD Anderson Cancer Center.
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Journal ArticleDOI
Chemical carcinogens. A review and analysis of the literature of selected chemicals and the establishment of the Gene-Tox Carcinogen Data Base. A report of the U.S. Environmental Protection Agency Gene-Tox Program.
Stephen Nesnow,M. Argus,Hinda Bergman,K. Chu,C. Frith,T. Helmes,R. McGaughy,Verne A. Ray,Thomas J. Slaga,Raymond W. Tennant,E. Weisburger +10 more
TL;DR: The literature on 506 selected chemicals has been evaluated for evidence that these chemicals induce tumors in experimental animals and this assessment comprises the Gene-Tox Carcinogen Data Base, which was analyzed and examined according to chemical class.
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Murine susceptibility to two-stage skin carcinogenesis is influenced by the agent used for promotion
TL;DR: Findings suggest that murine stock and strain-dependent differences in sensitivity to two-stage skin carcinogenesis may not be due to major differences in the metabolism of the initiating hydrocarbons, but are partially the consequences of the agents used for promotion.
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Polycyclic aromatic hydrocarbons: correlations between DNA adducts and ras oncogene mutations.
Jeffrey A. Ross,Stephen Nesnow +1 more
TL;DR: In this paper, a series of studies on the tumorigenic activities of polycyclic aromatic hydrocarbons (PAHs) in various experimental animal model systems, their ability to form PAH-DNA adducts in target tissues, and their abilities to mutate ras oncogenes in PAH induced tumors were described.
Journal Article
Adenomas induced by polycyclic aromatic hydrocarbons in strain A/J mouse lung correlate with time-integrated DNA adduct levels.
Jeffrey A. Ross,Garret B. Nelson,Katrina H. Wilson,James R. Rabinowitz,Anthony J. Galati,Gary D. Stoner,Stephen Nesnow,Marc J. Mass +7 more
TL;DR: The essentially identical induction of adenomas as a function of TIDAL values for these PAH suggests that the formation and persistence of DNA adducts determines their carcinogenic potency.
Journal Article
Formation of benzo(a)pyrene/DNA adducts and their relationship to tumor initiation in mouse epidermis
TL;DR: The results suggest a possible causal relationship between B(a)P/deoxyribonucleoside adduct formation and papilloma formation in mouse skin.