V
Verne A. Ray
Researcher at Pfizer
Publications - 22
Citations - 1002
Verne A. Ray is an academic researcher from Pfizer. The author has contributed to research in topics: Gene mutation & Point mutation. The author has an hindex of 14, co-authored 22 publications receiving 983 citations.
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Journal ArticleDOI
The Salmonella typhimurium/mammalian microsomal assay. A report of the U.S. Environmental Protection Agency Gene-Tox Program.
L.E. Kier,David Brusick,Angela E. Auletta,E.S. Von Halle,M.M. Brown,V.F. Simmon,Virginia C. Dunkel,Joyce McCann,Kristien Mortelmans,Michael J. Prival,T.K. Rao,Verne A. Ray +11 more
TL;DR: The Salmonella assay has been in use for almost 15 years and can be defined as a routine test for mutagenicity and for predicting potential carcinogenicity and it is recommended that it be regularly included in all genetic testing batteries.
Journal ArticleDOI
Chemical carcinogens. A review and analysis of the literature of selected chemicals and the establishment of the Gene-Tox Carcinogen Data Base. A report of the U.S. Environmental Protection Agency Gene-Tox Program.
Stephen Nesnow,M. Argus,Hinda Bergman,K. Chu,C. Frith,T. Helmes,R. McGaughy,Verne A. Ray,Thomas J. Slaga,Raymond W. Tennant,E. Weisburger +10 more
TL;DR: The literature on 506 selected chemicals has been evaluated for evidence that these chemicals induce tumors in experimental animals and this assessment comprises the Gene-Tox Carcinogen Data Base, which was analyzed and examined according to chemical class.
Journal ArticleDOI
Point mutations at the thymidine kinase locus in L5178Y mouse lymphoma cells. II. Test validation and interpretation
TL;DR: Data indicate this mammalian cell assay for gene mutations at the thymidine kinase (TK) locus can be expected to detect a majority of carcinogens as mutagens including some missed by more established point-mutation assays.
Journal ArticleDOI
Point mutations at the thymidine kinase locus in L5178Y mouse lymphoma cells: I. Application to genetic toxicological testing
TL;DR: The mouse lymphoma TK+/- leads to TK-/- mutagenesis assay is evaluated to determine if this somatic-cell test system would be a useful addition to the routine screening battery already used in the laboratory for the detection of chemical mutagens.
Journal ArticleDOI
An evaluation of the Escherichia coli WP2 and WP2uvrA reverse mutation assay
TL;DR: The general conclusion of the Working Group was the E. coli WP2 reverse mutation system is a valuable tool for mutagenesis research, but that there is no evidence from a review of the literature that this assay will contribute significantly to the results obtainable from careful application of the Ames Salmonella assay.