S
Stephen T. Lee
Researcher at United States Department of Agriculture
Publications - 131
Citations - 2016
Stephen T. Lee is an academic researcher from United States Department of Agriculture. The author has contributed to research in topics: Sudden death & Tremetone. The author has an hindex of 22, co-authored 130 publications receiving 1686 citations. Previous affiliations of Stephen T. Lee include Agricultural Research Service.
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Journal ArticleDOI
Phytochemicals: the good, the bad and the ugly?
TL;DR: Careful observation of cause and effect, followed by a coordinated approach to identify the responsible entities, has proved extremely fruitful in discovering roles for phytochemical constituents.
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Cyclopamine: from cyclops lambs to cancer treatment.
Stephen T. Lee,Kevin D. Welch,Kip E. Panter,Dale R. Gardner,Massoud Garrossian,Cheng-Wei Tom Chang +5 more
TL;DR: The steroidal alkaloid cyclopamine was isolated from the plant Veratrum californicum and identified as the teratogen responsible for craniofacial birth defects including cyclops in the offspring of sheep grazing on mountain ranges in the western United States.
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Detection of monofluoroacetate in Palicourea and Amorimia species.
Stephen T. Lee,Daniel Cook,Franklin Riet-Correa,James A. Pfister,William R. Anderson,Flávia Gontijo de Lima,Dale R. Gardner +6 more
TL;DR: An HPLC-APCI-MS method to detect and quantify MFA was developed and was used to investigate plant material from field collections and/or herbarium specimens of Mascagnia, Amorimia, and Palicourea species suspected of causing sudden death.
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Solid-phase extraction and HPLC-MS profiling of pyrrolizidine alkaloids and their N-oxides: a case study of Echium plantagineum.
TL;DR: The present case study of Echium plantagineum highlighted a higher ratio of N-oxides to the parent tertiary bases than has been previously reported, and a higher proportion of acetylated pyrrolizidine-N-oxide was observed in the flower heads relative to the leaves.
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Piperidine alkaloids: Human and food animal teratogens
TL;DR: There is abundant epidemiological evidence in humans that link maternal tobacco use with a high incidence of oral clefting in newborns; this association may be partly attributable to the presence of piperidine alkaloids in tobacco products.