Showing papers by "Stephen V. Faraone published in 1989"
TL;DR: Test the hypothesis that schizophrenic men and women may be at risk for experiencing different subtypes of the illness and suggest that men may be in danger of experiencing a more severe form of schizophrenia.
Abstract: This study begins to test the hypothesis that schizophrenic men and women may be at risk for experiencing different subtypes of the illnes. Given past research, hypotheses predict that schizophrenic men will have an earlier age of onset, poorer premorbid history, lower family morbid risk, and poorer course. Data consist of 332 schizophrenic patients diagnosed according to DSM-III and 713 of their first-degree relatives from the double-blind Iowa 500 and non-500 family studies. Survival analysis was used to estimate age of onset, and Stromgren's abridged method for age correction was used to estimate family morbidity risks. Findings support our hypotheses and suggest that men may be at risk for experiencing a more severe form of schizophrenia.
125 citations
TL;DR: The clustering of positive findings in certain domains suggests that the familial/sporadic strategy holds some promise for elucidating the role of genetic and environmental factors in schizophrenia.
Abstract: The existence of separate genetic and environmental forms of schizophrenia has been proposed as the basis for the probable heterogeneity in the etiology of schizophrenia. The rationale for a familial/sporadic strategy that compares positive versus negative family history cases and concordant versus discordant MZ twin pairs is discussed. A review of empirical findings from research utilizing the familial/sporadic strategy is presented. A number of methodological problems that have implications for the application of the strategy and the interpretation of results, such as misclassification, are discussed. It is concluded that the clustering of positive findings in certain domains suggests that this approach holds some promise for elucidating the role of genetic and environmental factors in schizophrenia.
23 citations
TL;DR: The results of a Monte Carlo simulation study with varying rates of misclassification are reported to determine the statistical power of comparisons between familial and sporadic groups.
21 citations
12 citations
TL;DR: The results confirm and extend previous findings that relatives of children with ADD have a significantly increased risk for ADD that appear to be independent of psychosocial factors.
9 citations
TL;DR: Those who had psychotic symptoms at 50% or more of their visits had higher neuroleptic doses, more tardive dyskinesia, and more affective symptoms than the other patients, and these groups were not, however, significantly different in their age of onset, years of education,duration of illness, duration of neuroleptics, or negative symptoms.
Abstract: For 2 years we assessed clinical state, and plasma neuroleptic and prolactin levels every 6 months in 105 male schizophrenic outpatients. The patients took a variety of neuroleptics at clinically determined doses. Those who had psychotic symptoms at 50% or more of their visits had higher neuroleptic doses, more tardive dyskinesia, and more affective symptoms than the other patients. These groups were not, however, significantly different in their age of onset, years of education, duration of illness, duration of neuroleptic exposure, or negative symptoms.
5 citations
TL;DR: Serum neuroleptic activity by radioreceptor assay and prolactin concentration were measured every 6 months for 2 years in 105 male schizophrenic outpatients and correction for blood-to-brain distribution may be a practical way to compare serum neuroleaptic activity from different neuroleptics.
Abstract: Serum neuroleptic activity by radioreceptor assay and prolactin concentration were measured every 6 months for 2 years in 105 male schizophrenic outpatients. The patients took a variety of neuroleptics at clinically determined doses. As expected, when four dissimilar neuroleptics were examined together, there was no significant correlation between serum neuroleptic activity and either equivalent neuroleptic dose or serum prolactin concentration. Moderate correlations were seen, however, when neuroleptic activity was standardized between neuroleptic drugs. Similar moderate correlations were seen when neuroleptic activity was corrected for the blood-to-brain distribution of each neuroleptic. These two correction techniques ranked corrected neuroleptic activity in very similar orders. Correction for blood-to-brain distribution may be a practical way to compare serum neuroleptic activity from different neuroleptics.
2 citations