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Stephen W. Russell
Researcher at University of Kansas
Publications - 29
Citations - 1978
Stephen W. Russell is an academic researcher from University of Kansas. The author has contributed to research in topics: Nitric oxide synthase & Cytokine. The author has an hindex of 18, co-authored 29 publications receiving 1944 citations. Previous affiliations of Stephen W. Russell include Research Triangle Park.
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Expression of the nitric oxide synthase gene in mouse macrophages activated for tumor cell killing. Molecular basis for the synergy between interferon-gamma and lipopolysaccharide.
TL;DR: Results here show that synthesis of nitric oxide (NO) was greatly increased when cells of the mouse macrophage cell line RAW 264.7 were costimulated with bacterial lipopolysaccharide (LPS) and interferon-gamma (IFN-Gamma) and LPS, compared to LPS alone, which paralleled increases in cytotoxicity.
Journal Article
Autocrine/Paracrine IFN-αβ Mediates the Lipopolysaccharide-Induced Activation of Transcription Factor Stat1α in Mouse Macrophages: Pivotal Role of Stat1α in Induction of the Inducible Nitric Oxide Synthase Gene
Jian Jun Gao,Michael B. Filla,Marion J. Fultz,Stefanie N. Vogel,Stephen W. Russell,William J. Murphy +5 more
TL;DR: The results show that LPS-induced IFN-αβ production, Stat1α activation, and nitrite accumulation closely parallel one another, suggesting that indirect activation of transcription factor Stat1 α by IFN -αβ is a critical determinant of L PS-mediated inducible nitric oxide synthase gene expression.
Journal Article
Comparative effects of various classes of mouse interferons on macrophage activation for tumor cell killing.
TL;DR: It is confirmed that significant quantitative differences exist between the various interferons with regard to their capacity to prime macrophages for tumor cell killing and indicated that to be an efficient activator each type of interferon must be combined with a second stimulus, such as LPS or HKLM.
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Transcriptional basis for hyporesponsiveness of the human inducible nitric oxide synthase gene to lipopolysaccharide/interferon-gamma.
Xiaoke Zhang,Victor E. Laubach,Evan W. Alley,Kevin A. Edwards,Paula A. Sherman,Stephen W. Russell,William J. Murphy +6 more
TL;DR: The work reported here resolves the controversy as to whether or not human monocytes/macrophages can produce nitric oxide when stimulated with lipopolysaccharide (LPS), with or without co‐stimulation by interferon‐γ(IFN‐γ).
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Role of endogenous interferon-beta in lipopolysaccharide-triggered activation of the inducible nitric-oxide synthase gene in a mouse macrophage cell line, J774.
TL;DR: Exogenous IFN-beta, but not TNF-alpha, produced by LPS-stimulated J774 cells specifically contributes, probably in an auto/paracrine fashion, to the activation of the i-NOS gene expression by L PS.