S
Steve E. Jacobsen
Researcher at University of California, Los Angeles
Publications - 14
Citations - 2416
Steve E. Jacobsen is an academic researcher from University of California, Los Angeles. The author has contributed to research in topics: DNA methylation & Adipose tissue. The author has an hindex of 9, co-authored 14 publications receiving 2210 citations.
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Journal ArticleDOI
Genome-wide high-resolution mapping and functional analysis of DNA methylation in arabidopsis.
Xiaoyu Zhang,Junshi Yazaki,Ambika Sundaresan,Shawn J. Cokus,Simon W. L. Chan,Huaming Chen,Ian R. Henderson,Paul Shinn,Matteo Pellegrini,Steve E. Jacobsen,Joseph R. Ecker +10 more
TL;DR: This is the first comprehensive DNA methylation map of an entire genome, at 35 base pair resolution, using the flowering plant Arabidopsis thaliana as a model and finds that pericentromeric heterochromatin, repetitive sequences, and regions producing small interfering RNAs are heavily methylated.
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Epigenetic maintenance of the vernalized state in Arabidopsis thaliana requires LIKE HETEROCHROMATIN PROTEIN 1
Sibum Sung,Yuehui He,Yuehui He,Tifani W Eshoo,Yosuke Tamada,Lianna M. Johnson,Kenji Nakahigashi,Koji Goto,Steve E. Jacobsen,Richard M. Amasino +9 more
TL;DR: It is reported that A. thaliana LIKE HETEROCHROMATIN PROTEIN 1 (LHP1) is necessary to maintain the epigenetically repressed state of FLC upon return to warm conditions typical of spring.
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A comparative analysis of DNA methylation across human embryonic stem cell lines
TL;DR: A comparative analysis of the genome-wide DNA methylation profiles from three human embryonic stem cell (HESC) lines suggests a possible but as yet unknown functional role for the highly methylated conserved non-CG sites in the regulation of HESCs.
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Intrauterine calorie restriction affects placental DNA methylation and gene expression
Pao-Yang Chen,Amit Ganguly,Liudmilla Rubbi,Luz D. Orozco,Marco Morselli,Davin Ashraf,Artur Jaroszewicz,Suhua Feng,Steve E. Jacobsen,Atsushi Nakano,Sherin U. Devaskar,Matteo Pellegrini +11 more
TL;DR: Several differentially methylated microRNAs that target genes associated with immunological, metabolic, gastrointestinal, cardiovascular, and neurological chronic diseases, as well as genes responsible for transplacental nutrient transfer and fetal development are identified.
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Genetic Analyses of DNA Methyltransferases in Arabidopsis thaliana
Xiaoyu Zhang,Steve E. Jacobsen +1 more
TL;DR: The genetic evidence presented here suggests that methylation at CG and non-CG sites functions in a partially redundant and locus-specific manner to regulate a wide range of developmental processes.