S
Steven D. Douglas
Researcher at Children's Hospital of Philadelphia
Publications - 338
Citations - 14047
Steven D. Douglas is an academic researcher from Children's Hospital of Philadelphia. The author has contributed to research in topics: Receptor & Immune system. The author has an hindex of 62, co-authored 337 publications receiving 13235 citations. Previous affiliations of Steven D. Douglas include Boston University & Baylor College of Medicine.
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Journal ArticleDOI
Lymphocyte subsets in healthy children from birth through 18 years of age : The pediatric AIDS clinical trials group P1009 study
William T. Shearer,Howard M. Rosenblatt,Rebecca Gelman,R Oyomopito,Susan Plaeger,E. Richard Stiehm,Diane W. Wara,Steven D. Douglas,Katherine Luzuriaga,Elizabeth J. McFarland,Ram Yogev,Mobeen H. Rathore,Wende Levy,Bobbie Graham,Stephen A. Spector +14 more
TL;DR: In this paper, the distribution of lymphocyte subsets in healthy urban-dwelling infants, children, and adolescents in the United States was determined by means of 3-color flow cytometry in a cross-sectional study of 807 HIV-unexposed children from birth through 18 years of age.
Journal Article
Human monocytes and macrophages express substance P and neurokinin-1 receptor.
TL;DR: The demonstration that human monocytes and macrophages express substance P and its receptor support the notion that substance P is biologically involved in regulating the functions of these cells in an autocrine fashion.
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Depressive and anxiety disorders in women with HIV infection
Mary F. Morrison,John M. Petitto,Thomas R. Ten Have,David R. Gettes,Margaret S. Chiappini,Anita L. Weber,Priscilla Brinker-Spence,Russell M. Bauer,Steven D. Douglas,Dwight L. Evans +9 more
TL;DR: HIV-seropositive women without current substance abuse exhibited a significantly higher rate of major depressive disorder and more symptoms of depression and anxiety than did a group of HIV-seronegative women with similar demographic characteristics.
Journal ArticleDOI
Leukocytosis and natural killer cell function parallel neurobehavioral fatigue induced by 64 hours of sleep deprivation.
David F. Dinges,Steven D. Douglas,Line Zaugg,D E Campbell,J M McMann,Wayne G. Whitehouse,Emily Carota Orne,Shiv Kapoor,E Icaza,Martin T. Orne +9 more
TL;DR: The physiologic leukocytosis and NK activity increases during deprivation were eliminated by recovery sleep in a manner parallel to neurobehavioral function, suggesting that the immune alterations may be associated with biological pressure for sleep.
Journal ArticleDOI
Association of depression with viral load, CD8 T lymphocytes, and natural killer cells in women with HIV infection.
Dwight L. Evans,Thomas R. Ten Have,Steven D. Douglas,David R. Gettes,Mary F. Morrison,Margaret S. Chiappini,Priscilla Brinker-Spence,Carla Job,Delinda E. Mercer,Yan Lin Wang,Dean G. Cruess,Benoit Dubé,Erik A. Dalen,Tiffany Brown,Russell M. Bauer,John M. Petitto +15 more
TL;DR: Findings provide the first evidence that depression may alter the function of killer lymphocytes in HIV-infected women and suggest that depression might decrease natural killer cell activity and lead to an increase in activated CD8 T lymphocytes and viral load.