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William T. Shearer
Researcher at Baylor College of Medicine
Publications - 316
Citations - 18696
William T. Shearer is an academic researcher from Baylor College of Medicine. The author has contributed to research in topics: Antibody & Severe combined immunodeficiency. The author has an hindex of 54, co-authored 316 publications receiving 17487 citations. Previous affiliations of William T. Shearer include Boston Children's Hospital.
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Journal ArticleDOI
Reduction of maternal-infant transmission of human immunodeficiency virus type 1 with zidovudine treatment. Pediatric AIDS Clinical Trials Group Protocol 076 Study Group.
Edward M. Connor,Rhoda S. Sperling,Richard D. Gelber,Pavel Kiselev,Gwendolyn B. Scott,Mary Jo O'Sullivan,Russell Vandyke,Mohammed Bey,William T. Shearer,Robert L. Jacobson,Eleanor Jimenez,Edward O’neill,Brigitte Bazin,Jean François Delfraissy,Mary Culnane,Robert W. Coombs,Mary Elkins,Jack Moye,Pamela Stratton,James Balsley +19 more
TL;DR: In pregnant women with mildly symptomatic HIV disease and no prior treatment with antiretroviral drugs during the pregnancy, a regimen consisting of zidovudine given ante partum and intra partum to the mother and to the newborn for six weeks reduced the risk of maternal-infant HIV transmission by approximately two thirds.
Journal ArticleDOI
Reduction of maternal-infant transmission of human immunodeficiency virus 1 with zidovudine treatment
Edward M. Connor,Rhoda S. Sperling,Richard D. Gelber,Pavel Kiselev,Gwendolyn B. Scott,Mary J. O'Sullivan,Russell Vandyke,Mohammed Bey,William T. Shearer,R Jacobson,Eleanor Jimenez,Edward O’neill,Brigitte Bazin,Jean François Delfraissy,Mary Culnane,Robert W. Coombs,Mary Elkins,Jack Moye,Pamela Stratton,James Balsley +19 more
TL;DR: It was shown that AZT decreased the maternal-infant transmission of HIV and helped decrease infant mortality due to the viral infection.
Journal ArticleDOI
Lymphocyte subsets in healthy children from birth through 18 years of age : The pediatric AIDS clinical trials group P1009 study
William T. Shearer,Howard M. Rosenblatt,Rebecca Gelman,R Oyomopito,Susan Plaeger,E. Richard Stiehm,Diane W. Wara,Steven D. Douglas,Katherine Luzuriaga,Elizabeth J. McFarland,Ram Yogev,Mobeen H. Rathore,Wende Levy,Bobbie Graham,Stephen A. Spector +14 more
TL;DR: In this paper, the distribution of lymphocyte subsets in healthy urban-dwelling infants, children, and adolescents in the United States was determined by means of 3-color flow cytometry in a cross-sectional study of 807 HIV-unexposed children from birth through 18 years of age.
Journal ArticleDOI
The Severe and Moderate Phenotypes of Heritable Mac-1, LFA-1 Deficiency: Their Quantitative Definition and Relation to Leukocyte Dysfunction and Clinical Features
Donald C. Anderson,Frank C. Schmalsteig,Milton J. Finegold,Bonnie J. Hughes,Robert Rothlein,Linda J. Miller,Steve Kohl,Michael F. Tosi,Robert L. Jacobs,Thomas C. Waldrop,Armond S. Goldman,William T. Shearer,Timothy A. Springer +12 more
TL;DR: In vivo abnormalities of leukocyte mobilization reflect the critical roles of Mac-1 glycoproteins in adhesive events required for endothelial margination and tissue exudation as well as complement- or antibody-dependent cytotoxicity.
Journal ArticleDOI
Transplantation Outcomes for Severe Combined Immunodeficiency, 2000–2009
Sung-Yun Pai,Brent R. Logan,Linda M. Griffith,Rebecca H. Buckley,Roberta E. Parrott,Christopher C. Dvorak,Neena Kapoor,Imelda C. Hanson,Alexandra H. Filipovich,Soma Jyonouchi,Kathleen E. Sullivan,Trudy N. Small,Lauri Burroughs,Suzanne Skoda-Smith,Ann E. Haight,Audrey Grizzle,Michael A. Pulsipher,Ka Wah Chan,Ramsay Fuleihan,Elie Haddad,Brett Loechelt,Victor M. Aquino,Alfred P. Gillio,Jeffrey H. Davis,Alan P. Knutsen,Angela R. Smith,Theodore B. Moore,Marlis L. Schroeder,Frederick D. Goldman,James A. Connelly,Matthew H. Porteus,Qun Xiang,William T. Shearer,Thomas A. Fleisher,Donald B. Kohn,Jennifer M. Puck,Luigi D. Notarangelo,Morton J. Cowan,Richard J. O'Reilly +38 more
TL;DR: Transplants from donors other than matched siblings were associated with excellent survival among infants with SCID identified before the onset of infection.