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Steven Frey
Researcher at International AIDS Vaccine Initiative
Publications - 9
Citations - 1867
Steven Frey is an academic researcher from International AIDS Vaccine Initiative. The author has contributed to research in topics: Epitope & Monoclonal antibody. The author has an hindex of 5, co-authored 9 publications receiving 1777 citations.
Papers
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Journal ArticleDOI
Broad and potent neutralizing antibodies from an African donor reveal a new HIV-1 vaccine target.
Laura M. Walker,Sanjay Phogat,Po-Ying Chan-Hui,Denise Wagner,Pham Phung,Julie L. Goss,Terri Wrin,Melissa Simek,Steven P. Fling,Jennifer L. Mitcham,Jennifer Lehrman,Frances Priddy,Ole A. Olsen,Steven Frey,Phillip W. Hammond,Protocol G. Principal Investigators,Stephen M. Kaminsky,Timothy J. Zamb,Matthew Moyle,Wayne C. Koff,Pascal Poignard,Dennis R. Burton,Dennis R. Burton +22 more
TL;DR: High-throughput screening has revealed two new broadly neutralizing antibodies from a clade A–infected donor in Africa, which exhibit great potency and are able to neutralize a wide range of viruses from many different clades.
Patent
Human immunodeficiency virus (hiv)-neutralizing antibodies
Po-Ying Chan-Hui,Katherine Doores,Michael Huber,Stephen M. Kaminsky,Steven Frey,Ole A. Olsen,Jennifer L. Mitcham,Matthew Moyle,Sanjay Phogat,Dennis R. Burton,Laura M. Walker,Pascal Poignard,Wayne C. Koff,Melissa Danielle De Jean De St. Marcel Simek-Lemos +13 more
TL;DR: In this paper, a method for obtaining a broadly neutralizing antibody (bNab), including screening memory B cells from a donor PBMC sample for neutralization activity against a plurality of HIV-1 species, cloning a memory B cell that exhibits broad neutralization capability; and rescuing a monoclonal antibody from that memory b cell culture.
Patent
Granulocyte-macrophage colony-stimulating factor (GM-CSF) neutralizing antibodies
TL;DR: In this article, a GM-CSF neutralizing human monoclonal antibody, 1783J22, was described and further characterized by its ability to bind epitopes from multiple species.
Patent
Broadly neutralizing human immunodeficiency virus type 1 (HIV-1) GP120-specific monoclonal antibody
Po-Ying Chan-Hui,Katherine Doores,Michael Huber,Stephen M. Kaminsky,Steven Frey,Ole A. Olsen,Jennifer L. Mitcham,Matthew Moyle,Sanjay Phogat,Dennis R. Burton,Laura M. Walker,Pascal Poignard,Wayne C. Koff,Melissa Danielle De Jean De St. Marcel Simek-Lemos +13 more
TL;DR: In this article, a method for obtaining a broadly neutralizing antibody (bNab), including screening memory B cells from a donor PBMC sample for neutralization activity against a plurality of HIV-1 species, cloning a memory B cell that exhibits broad neutralization capability; and rescuing a monoclonal antibody from that memory b cell culture.
Patent
Monoclonal antibodies directed against trimeric forms of the HIV-1 envelope glycoprotein with broad and potent neutralizing activity
Po-Ying Chan-Hui,Steven Frey,Olsen Ole,Jennifer L. Mitcham,Matthew Moyle,Sanjay Phogat,Dennis R. Burton,Laura M. Walker,Pascal Poignard,Wayne C. Koff,De Jean De St Marcel Simek-Lemos Melissa D +10 more
TL;DR: In this article, a method for obtaining a broadly neutralizing antibody (bNab), including screening memory B cells from a donor PBMC sample for neutralization activity against a plurality of HIV-1 species, cloning a memory B cell that exhibits broad neutralization capability; and rescuing a monoclonal antibody from that memory b cell culture.