S
Steven G. Blanchard
Researcher at Research Triangle Park
Publications - 58
Citations - 8278
Steven G. Blanchard is an academic researcher from Research Triangle Park. The author has contributed to research in topics: Receptor & Peroxisome proliferator-activated receptor. The author has an hindex of 33, co-authored 58 publications receiving 7962 citations. Previous affiliations of Steven G. Blanchard include GlaxoSmithKline.
Papers
More filters
Journal ArticleDOI
Bile Acids: Natural Ligands for an Orphan Nuclear Receptor
Derek J. Parks,Steven G. Blanchard,Randy K. Bledsoe,Gyan Chandra,Thomas G. Consler,Steven A. Kliewer,Julie B. Stimmel,Timothy M. Willson,Ann Marie Zavacki,David D. Moore,Jürgen M. Lehmann +10 more
TL;DR: Results provide evidence for a nuclear bile acid signaling pathway that may regulate cholesterol homeostasis and modulated interaction of FXR with a peptide derived from steroid receptor coactivator 1.
Journal ArticleDOI
Molecular Recognition of Fatty Acids by Peroxisome Proliferator–Activated Receptors
H. Eric Xu,Millard H. Lambert,Valerie G. Montana,Derek J. Parks,Steven G. Blanchard,Peter Brown,Daniel D. Sternbach,Jürgen M. Lehmann,G. Bruce Wisely,Timothy M. Willson,Steven A. Kliewer,Michael V. Milburn +11 more
TL;DR: The peroxisome proliferator-activated receptors (PPARs) are nuclear receptors for fatty acids (FAs) that regulate glucose and lipid homeostasis as mentioned in this paper.
Journal ArticleDOI
Orphan Nuclear Receptors Constitutive Androstane Receptor and Pregnane X Receptor Share Xenobiotic and Steroid Ligands
Linda B. Moore,Derek J. Parks,Stacey A. Jones,Randy K. Bledsoe,Thomas G. Consler,Julie B. Stimmel,Bryan Goodwin,Christopher Liddle,Steven G. Blanchard,Timothy M. Willson,Jon L. Collins,Steven A. Kliewer +11 more
TL;DR: It is demonstrated that several of the compounds that regulate mouse and human CAR, including natural steroids, bind directly to the receptors and suggest that CAR, like PXR, is a steroid receptor that is capable of recognizing structurally diverse compounds.
Journal ArticleDOI
Functional consequences of cysteine modification in the ligand binding sites of peroxisome proliferator activated receptors by GW9662.
Lisa M. Leesnitzer,Derek J. Parks,Randy K. Bledsoe,Jeff E. Cobb,Jon L. Collins,Thomas G. Consler,Roderick G. Davis,Emily A. Hull-Ryde,James M. Lenhard,Lisa G. Patel,Kelli D. Plunket,Jennifer L. Shenk,Julie B. Stimmel,Christina Therapontos,Timothy M. Willson,Steven G. Blanchard +15 more
TL;DR: The selective and irreversible nature of GW9662 treatment, and the observation that activity is maintained in cell culture experiments, suggests that this compound may be a useful tool for elucidation of the role of PPARgamma in biological processes.
Journal ArticleDOI
Conjugated linoleic acid is a potent naturally occurring ligand and activator of PPARα
Silvia Y. Moya-Camarena,John P. Vanden Heuvel,Steven G. Blanchard,Lisa A. Leesnitzer,Martha A. Belury +4 more
TL;DR: CLA is a high affinity ligand and activator of peroxisome proliferator-activated receptor alpha (PPARalpha) and induces accumulation of PPAR-responsive mRNAs in a rat hepatoma cell line and its effects on lipid metabolism may be attributed to transcriptional events associated with this nuclear receptor.