S
Steven J. Schrodi
Researcher at University of Wisconsin-Madison
Publications - 86
Citations - 7527
Steven J. Schrodi is an academic researcher from University of Wisconsin-Madison. The author has contributed to research in topics: Single-nucleotide polymorphism & Medicine. The author has an hindex of 30, co-authored 71 publications receiving 6935 citations. Previous affiliations of Steven J. Schrodi include Baylor College of Medicine & Marshfield Clinic.
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Journal ArticleDOI
(5R)-5-Hydroxytriptolide (LLDT-8) induces substantial epigenetic mediated immune response network changes in fibroblast-like synoviocytes from rheumatoid arthritis patients.
Shicheng Guo,Jia Liu,Ting Jiang,Dungyang Lee,Rongsheng Wang,Xinpeng Zhou,Yehua Jin,Yi Shen,Yan Wang,Fengmin Bai,Qin Ding,Grace Wang,Jianyong Zhang,Xiaodong Zhou,Steven J. Schrodi,Steven J. Schrodi,Dongyi He +16 more
TL;DR: The results indicated that the LLDT-8 would mainly influence the FLS cells systemically and specially in the process of immune related pathways as well as the enrichment of immune response.
Journal ArticleDOI
A gene-based recessive diplotype exome scan discovers FGF6, a novel hepcidin-regulating iron-metabolism gene
Shicheng Guo,Shuai Jiang,Narendranath Epperla,Yanyun Ma,Mehdi Maadooliat,Mehdi Maadooliat,Zhan Ye,Brent F. Olson,Minghua Wang,Terrie Kitchner,Jeffrey Joyce,Peng An,Fudi Wang,Robert Strenn,Joseph J. Mazza,Jennifer K. Meece,Wenyu Wu,Li Jin,Judith A. Smith,Jiucun Wang,Steven J. Schrodi,Steven J. Schrodi +21 more
TL;DR: This work proposed and conducted a gene-based compound heterozygosity test to reveal additional genes underlying complex diseases and revealed a novel susceptibility hemochromatosis gene, extending the understanding of the mechanisms involved in iron metabolism.
Posted ContentDOI
MicroRNA variants and HLA-miRNA interactions are novel rheumatoid arthritis susceptibility factors
Shicheng Guo,Yehua Jin,Jieru Zhou,Qi Zhu,Ting Jiang,Yanqin Bian,Runrun Zhang,Cen Chang,Lingxia Xu,Jie Shen,Xinchun Zheng,Yi Shen,Yingying Qin,Jihong Chen,Xiaorong Tang,Peng Cheng,Qin Ding,Yuanyuan Zhang,Jia Liu,Qingqing Cheng,Mengru Guo,Zhaoyi Liu,Weifang Qiu,Yi Qian,Yang Sun,Yu Shen,Hong Nie,Steven J. Schrodi,Dongyi He +28 more
TL;DR: The study suggests that miRNAs might be interesting targets to accelerate the understanding of the pathogenesis and drug development for rheumatoid arthritis and demonstrates targets of the significant miRN as showing enrichment in immune related genes and FDA approved drug target genes.
Journal ArticleDOI
Reduced Anti-Histone Antibodies and Increased Risk of Rheumatoid Arthritis Associated with a Single Nucleotide Polymorphism in PADI4 in North Americans
Aisha M Mergaert,Mandar Bawadekar,Thai Q Nguyen,Laura Massarenti,Caitlyn L. Holmes,Ryan Rebernick,Steven J. Schrodi,Miriam A. Shelef +7 more
TL;DR: If single nucleotide polymorphism rs2240335 in PADI4, whose G allele is associated with reduced PAD4 in neutrophils, correlates with NETs, anti-histone antibodies, and rheumatoid arthritis susceptibility in North Americans is determined.
Journal ArticleDOI
Genome-wide association scan in psoriasis: new insights into chronic inflammatory disease.
TL;DR: This study provides evidence of a single-nucleotide polymorphism (SNP), 35 kb upstream of HLA-C, which is stronger than Cw*0602 – the variant traditionally attributed to the MHC-linked psoriasis-susceptibility effect, and is the first to report psoriatic arthritis association on a genome-wide scale.