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Steven J. Smith
Researcher at University of California, San Francisco
Publications - 4
Citations - 1389
Steven J. Smith is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Chylomicron & Receptor. The author has an hindex of 3, co-authored 4 publications receiving 1322 citations. Previous affiliations of Steven J. Smith include Gladstone Institutes & University of Texas Southwestern Medical Center.
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Journal ArticleDOI
Obesity resistance and multiple mechanisms of triglyceride synthesis in mice lacking Dgat.
Steven J. Smith,Sylvaine Cases,Dalan R. Jensen,Hubert Chen,Eric Sande,Bryan Tow,David A. Sanan,Jacob Raber,Robert H. Eckel,Robert V. Farese +9 more
TL;DR: It is shown that Dgat-deficient (Dgat−/−) mice are viable and can still synthesize triglycerides, and these mice are lean and resistant to diet-induced obesity.
Journal ArticleDOI
DGAT1 is not essential for intestinal triacylglycerol absorption or chylomicron synthesis.
Kimberly K. Buhman,Steven J. Smith,S. Stone,Joyce J. Repa,Jinny S. Wong,F. F. Knapp,Betty J. Burri,Robert L. Hamilton,Nada A. Abumrad,Robert V. Farese +9 more
TL;DR: Interestingly, DGAT1 was not essential for quantitative dietary triacylglycerol absorption, even in mice fed a high fat diet, or for the synthesis of chylomicrons, and analysis of intestine from Dgat1 −/−mice revealed activity for two other enzymes, DGat2 and diacyl glycerol transacylase, that catalyze triACYlglycersol synthesis and apparently help to compensate for the absence of DGAT 1.
Journal ArticleDOI
Massive xanthomatosis and altered composition of atherosclerotic lesions in hyperlipidemic mice lacking acyl CoA:cholesterol acyltransferase 1.
Michel Accad,Steven J. Smith,Steven J. Smith,Dale L. Newland,David A. Sanan,Lloyd E. King,MacRae F. Linton,Sergio Fazio,Robert V. Farese,Robert V. Farese +9 more
TL;DR: The marked alterations in cholesterol homeostasis indicate that selectively inhibiting ACAT1 in the setting of severe hyperlipidemia may have detrimental consequences.