R
Raj Kishore
Researcher at Temple University
Publications - 166
Citations - 8376
Raj Kishore is an academic researcher from Temple University. The author has contributed to research in topics: Progenitor cell & Stem cell. The author has an hindex of 45, co-authored 149 publications receiving 6886 citations. Previous affiliations of Raj Kishore include Cleveland Clinic & Indian Institute of Technology Bhubaneswar.
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Journal ArticleDOI
Embryonic Stem Cell-Derived Exosomes Promote Endogenous Repair Mechanisms and Enhance Cardiac Function Following Myocardial Infarction
Mohsin Khan,Emily Nickoloff,Tatiana Abramova,Jennifer M. Johnson,Suresh K Verma,Prasanna Krishnamurthy,Alexander R Mackie,Erin E Vaughan,Venkata Naga Srikanth Garikipati,Cindy Benedict,Veronica Ramirez,Erin Lambers,Aiko Ito,Erhe Gao,Sol Misener,Timothy S. Luongo,John W. Elrod,Gangjian Qin,Steven R. Houser,Walter J. Koch,Raj Kishore +20 more
TL;DR: It is demonstrated that mouse ESC-derived exosomes (mES Ex) possess ability to augment function in infarcted hearts and provide a novel cell-free system that uses the immense regenerative power of ES cells while avoiding the risks associated with direct ES or ES-derived cell transplantation and risk of teratomas.
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Exosomes From Human CD34+ Stem Cells Mediate Their Proangiogenic Paracrine Activity
Susmita Sahoo,Ekaterina Klychko,Tina Thorne,Sol Misener,Kathryn M. Schultz,Meredith Millay,Aiko Ito,Ting Liu,Christine Kamide,Hemant Agrawal,Harris Perlman,Gangjian Qin,Raj Kishore,Douglas W. Losordo +13 more
TL;DR: CD34+ exosomes may represent a significant component of the paracrine effect of progenitor cell transplantation for therapeutic angiogenesis and are demonstrated to have independent angiogenic activity both in vitro and in vivo.
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Hypoxic Preconditioning Enhances the Benefit of Cardiac Progenitor Cell Therapy for Treatment of Myocardial Infarction by Inducing CXCR4 Expression
Yao Liang Tang,Wuqiang Zhu,Min Cheng,Lijuan Chen,John Zhang,Tao Sun,Raj Kishore,M. Ian Phillips,Douglas W. Losordo,Gangjian Qin +9 more
TL;DR: It is found that hypoxic preconditioning increased CXCR4 expression in CLK (cardiosphere-derived, Lin−c-kit+ progenitor) cells and markedly augmented CLK cell migration and recruitment to the ischemic myocardium and that therapies targeting this axis may enhance cardiac-progenitor cell–based regenerative therapy.
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IL-10 Inhibits Inflammation and Attenuates Left Ventricular Remodeling After Myocardial Infarction via Activation of STAT3 and Suppression of HuR
Prasanna Krishnamurthy,Johnson Rajasingh,Erin Lambers,Gangjian Qin,Douglas W. Losordo,Raj Kishore +5 more
TL;DR: It is demonstrated that IL-10 suppresses inflammatory response and contributes to improved LV function and remodeling by inhibiting fibrosis via suppression of HuR/MMP-9 and by enhancing capillary density through activation of STAT3.
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Sonic hedgehog myocardial gene therapy: tissue repair through transient reconstitution of embryonic signaling.
Kengo Fukushima Kusano,Roberto Pola,Toshinori Murayama,Cynthia Curry,Atsuhiko Kawamoto,Atsushi Iwakura,Satoshi Shintani,Masaaki,Jun Asai,Tengiz Tkebuchava,Tina Thorne,Hideya Takenaka,Ryuichi Aikawa,David A. Goukassian,Patrick von Samson,Hiromichi Hamada,Young Sup Yoon,Marcy Silver,Elizabeth Eaton,Hong Ma,Lindsay Heyd,Marianne Kearney,William E. Munger,Jeffery A. Porter,Raj Kishore,Douglas W. Losordo +25 more
TL;DR: Analysis of intramyocardial gene transfer of naked DNA encoding human Shh suggests that Shh gene therapy may have considerable therapeutic potential in individuals with acute and chronic myocardial ischemia by triggering expression of multiple trophic factors and engendering tissue repair in the adult heart.