P
Prasanna Krishnamurthy
Researcher at University of Alabama at Birmingham
Publications - 80
Citations - 3265
Prasanna Krishnamurthy is an academic researcher from University of Alabama at Birmingham. The author has contributed to research in topics: Stem cell & Inflammation. The author has an hindex of 27, co-authored 73 publications receiving 2524 citations. Previous affiliations of Prasanna Krishnamurthy include East Tennessee State University James H. Quillen College of Medicine & Loyola University Chicago.
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Journal ArticleDOI
Embryonic Stem Cell-Derived Exosomes Promote Endogenous Repair Mechanisms and Enhance Cardiac Function Following Myocardial Infarction
Mohsin Khan,Emily Nickoloff,Tatiana Abramova,Jennifer M. Johnson,Suresh K Verma,Prasanna Krishnamurthy,Alexander R Mackie,Erin E Vaughan,Venkata Naga Srikanth Garikipati,Cindy Benedict,Veronica Ramirez,Erin Lambers,Aiko Ito,Erhe Gao,Sol Misener,Timothy S. Luongo,John W. Elrod,Gangjian Qin,Steven R. Houser,Walter J. Koch,Raj Kishore +20 more
TL;DR: It is demonstrated that mouse ESC-derived exosomes (mES Ex) possess ability to augment function in infarcted hearts and provide a novel cell-free system that uses the immense regenerative power of ES cells while avoiding the risks associated with direct ES or ES-derived cell transplantation and risk of teratomas.
Journal ArticleDOI
IL-10 Inhibits Inflammation and Attenuates Left Ventricular Remodeling After Myocardial Infarction via Activation of STAT3 and Suppression of HuR
Prasanna Krishnamurthy,Johnson Rajasingh,Erin Lambers,Gangjian Qin,Douglas W. Losordo,Raj Kishore +5 more
TL;DR: It is demonstrated that IL-10 suppresses inflammatory response and contributes to improved LV function and remodeling by inhibiting fibrosis via suppression of HuR/MMP-9 and by enhancing capillary density through activation of STAT3.
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Interleukin-10 Treatment Attenuates Pressure Overload–Induced Hypertrophic Remodeling and Improves Heart Function via Signal Transducers and Activators of Transcription 3–Dependent Inhibition of Nuclear Factor-κB
Suresh K Verma,Prasanna Krishnamurthy,David Y. Barefield,Neha Singh,Rajesh Gupta,Erin Lambers,Melissa Thal,Alexander R Mackie,Eneda Hoxha,Veronica Ramirez,Gangjian Qin,Sakthivel Sadayappan,Asish K. Ghosh,Raj Kishore +13 more
TL;DR: IL-10 treatment is suggested as a potential therapeutic approach to limit the progression of pressure overload–induced adverse cardiac remodeling and hypertrophy.
Journal ArticleDOI
Interleukin-10 deficiency impairs bone marrow-derived endothelial progenitor cell survival and function in ischemic myocardium
Prasanna Krishnamurthy,Melissa Thal,Suresh K Verma,Eneda Hoxha,Erin Lambers,Veronica Ramirez,Gangjian Qin,Douglas W. Losordo,Raj Kishore +8 more
TL;DR: In this paper, the IL-10-treatment was shown to increase the survival and function of EPCs after transplantation in the ischemic myocardium, leading to increased EPC retention and their association with the vascular structures.
Journal ArticleDOI
MicroRNA-9 inhibits hyperglycemia-induced pyroptosis in human ventricular cardiomyocytes by targeting ELAVL1.
Prince Jeyabal,Rajarajan Amirthalingam Thandavarayan,Darukeshwara Joladarashi,Sahana Suresh Babu,Shashirekha Krishnamurthy,Arvind Bhimaraj,Keith A. Youker,Raj Kishore,Prasanna Krishnamurthy,Prasanna Krishnamurthy +9 more
TL;DR: This study demonstrates that ELAVL1 expression augmented with a concomitant increase in caspase-1 and IL-1 beta expression in human hearts and human ventricular cardiomyocytes under hyperglycemic condition and highlights the potential therapeutic implications of targeting miR-9/ELAVL 1 in preventing cardiomeocyte cell loss during HF in diabetics.