Steven Whitebread

TL;DR: The expression cloning of a novel Y-type receptor from rat hypothalamus is reported, which is thought to be the postulated 'feeding' receptor and may provide a new method for the study and treatment of obesity and eating disorders.

TL;DR: There is a good correlation between the affinities of the selected agonists and antagonists for the two subtypes in the various tissues tested which is a usual requirement for receptor classification.

TL;DR: An association metric is developed to prioritize those new off-targets that explained side effects better than any known target of a given drug, creating a drug–target–adverse drug reaction network and may have wide application to de-risking toxicological liabilities in drug discovery.

TL;DR: For the first time, the rationale, strategies and methodologies for in vitro pharmacological profiling at four major pharmaceutical companies are presented and illustrated with examples of their impact on the drug discovery process.

TL;DR: In this article, the authors review the development of this tool for drug discovery, its appropriate use and predictive value, and its application in drug discovery and propose a method to use this tool to predict clinical adverse effects.