다중혈관 관상동맥 환자에서 y-문합을 이용하여 양쪽 내흉동맥만을 사용한 우회술의 조기 성적

THE DESIGN AND ANALYSIS OF EXPERIMENTS. By Oscar Kempthorne. New York, John Wiley and Sons, Inc., 1952. 631 pp. $8.50. This book by a teacher of statistics (as well as a consultant for \"experimenters\") is a comprehensive study of the philosophical background for the statistical design of experiment. It is necessary to have some facility with algebraic notation and manipulation to be able to use the volume intelligently. The problems are presented from the theoretical point of view, without such practical examples as would be helpful for those not acquainted with mathematics. The mathematical justification for the techniques is given. As a somewhat advanced treatment of the design and analysis of experiments, this volume will be interesting and helpful for many who approach statistics theoretically as well as practically. With emphasis on the \"why,\" and with description given broadly, the author relates the subject matter to the general theory of statistics and to the general problem of experimental inference. MARGARET J. ROBERTSON

The Design and Analysis of Experiments

[신간의 별자리x] 우리/미술, 그리고 ‘슬픔의 박물관’

基礎講座 電気泳動(Electrophoresis)

https://recipp.ipp.pt/bitstream/10400.22/3012/4/ART_LuciaSantos_2010_GRAQ.pdf

Ecotoxicological aspects related to the presence of pharmaceuticals in the aquatic environment

Comparison of on‐column and splitless injection in capillary gas chromatography coupled with atomic emission detection

Electromembrane extraction is affected by acid-base equilibria of the extracted substances as well as coupled equilibria associated with the partitioning of neutral substances to the supported liquid membrane. A theoretical model for this was developed and verified experimentally in the current work using pure 2-nitrophenyl octyl ether as supported liquid membrane. From this model, extraction efficiency as a function of pH can be predicted. Substances with log P   2 are generally extracted with high efficiency when acceptor pH < pKaH - log P. Twelve basic drug substances (2.07 < log P < 6.57 and 6.03 < pKaH  < 10.47) were extracted under different pH conditions with 2-nitrophenyl octyl ether as supported liquid membrane and fitted to the model. Seven of the drug substances behaved according to the model, while those with log P close to 2.0 deviated from prediction. The deviation was most probably caused by deprotonation and ion pairing within the supporting liquid membrane. Measured partition coefficients (log P) between 2-nitrophenyl octyl ether and water, were similar to traditional log P values between n-octanol and water. Thus, the latter have potential for pKaH - log P predictions.

Influence of acid‐base dissociation equilibria during electromembrane extraction

Fluorescent aptamer beacons (FABs) are a major category of biosensors widely used in environmental analysis. However, due to their low compatibility, it is difficult to use the common FABs for biological samples. To overcome this challenge, construction of FABs with complex structures to adapt the nature of biological samples is currently in progress in this field. Unlike previous works, we moved our range of vision from the FAB itself to the biological sample. Inspired by this idea, in this work, flat membrane-based liquid-phase microextraction (FM-LPME) with sufficient sample cleanup and preconcentration capacities was integrated with FABs. With the merits of both FM-LPME and FABs, the integrated LPME-FAB system displayed a clear synergistic enhancement for target analysis. Specifically, LPME in the LPME-FAB system provided purified and enriched Hg2+ for the FAB recognition, while the FAB recognition event promoted the extraction efficiency of LPME. Due to superior performances, the LPME-FAB system achieved highly sensitive analysis of Hg2+ in urine samples with a detection limit of 27 nM and accuracies in the range of 98-113%. To the best of our knowledge, this is the first time that an integrated LPME-FAB system was constructed for target analysis in biological samples. We believe that this study will provide a new insight into the next generation of biosensors, where the integration of sample preparation with detection probes is as important as the design of complex probes in the field of bioanalysis.

Versatile Integration of Liquid-Phase Microextraction and Fluorescent Aptamer Beacons: A Synergistic Effect for Bioanalysis.

This fundamental work investigated the removal of sodium dodecyl sulfate (SDS) from highly concentrated samples by electromembrane extraction (EME). SDS concentrations were in the range of 0.1–1.0% w/v, covering both sub- and super-critical micellar concentrations (CMC). Under optimal conditions, we extracted SDS from 100 μL aqueous sample, through 3 μL supported liquid membrane (SLM) and into 200 μL 10 mM NaOH in water as waste solution. The SLM comprised 1.0% w/w Aliquat 336 in 1-nonanol, and extraction voltage was 5 V. From 0.1% SDS samples, EME removed 100% during 30 minutes operation (100% clearance). SDS concentration above the critical micellar concentration (CMC) challenged the capacity of the system. Thus, to reach 100% clearance from 0.5% samples, we extracted for 120 minutes and replenished the SLM after 60 minutes. Increasing the membrane area of the SLM from 28 mm2 to 43 mm2 provided 100% clearance from 0.5% samples after 30 min EME. Complete clearance of 1.0% SDS samples was not achieved under the tested conditions, and maximal clearance was 60%. Mass balance experiments demonstrated that most of the removed SDS is trapped in the SLM, rather than transferring to the waste solution. For super-CMC samples, aggregation of SDS in the SLM exceeded the SLM capacity and impeded further mass transfer.

Stig Pedersen-Bjergaard

Papers

Comparison of on‐column and splitless injection in capillary gas chromatography coupled with atomic emission detection

Influence of acid‐base dissociation equilibria during electromembrane extraction

Versatile Integration of Liquid-Phase Microextraction and Fluorescent Aptamer Beacons: A Synergistic Effect for Bioanalysis.

Electromembrane extraction of sodium dodecyl sulfate from highly concentrated solutions

Introduction to Spectroscopic Methods