S
Stig Petersen
Researcher at Google
Publications - 15
Citations - 41142
Stig Petersen is an academic researcher from Google. The author has contributed to research in topics: Artificial neural network & Protein structure prediction. The author has an hindex of 11, co-authored 14 publications receiving 19136 citations.
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Journal ArticleDOI
Human-level control through deep reinforcement learning
Volodymyr Mnih,Koray Kavukcuoglu,David Silver,Andrei Rusu,Joel Veness,Marc G. Bellemare,Alex Graves,Martin Riedmiller,Andreas K. Fidjeland,Georg Ostrovski,Stig Petersen,Charles Beattie,Amir Sadik,Ioannis Antonoglou,Helen King,Dharshan Kumaran,Daan Wierstra,Shane Legg,Demis Hassabis +18 more
TL;DR: This work bridges the divide between high-dimensional sensory inputs and actions, resulting in the first artificial agent that is capable of learning to excel at a diverse array of challenging tasks.
Journal ArticleDOI
Highly accurate protein structure prediction with AlphaFold
John M. Jumper,Richard O. Evans,Alexander Pritzel,Tim Green,Michael Figurnov,Olaf Ronneberger,Kathryn Tunyasuvunakool,Russell Bates,Augustin Žídek,Anna Potapenko,Alex Bridgland,Clemens Meyer,Simon A. A. Kohl,Andrew J. Ballard,Andrew Cowie,Bernardino Romera-Paredes,Stanislav Nikolov,R. D. Jain,Jonas Adler,Trevor Back,Stig Petersen,David Reiman,Ellen Clancy,Michal Zielinski,Martin Steinegger,Michalina Pacholska,Tamas Berghammer,Sebastian Bodenstein,David L. Silver,Oriol Vinyals,Andrew W. Senior,Koray Kavukcuoglu,Pushmeet Kohli,Demis Hassabis +33 more
TL;DR: For example, AlphaFold as mentioned in this paper predicts protein structures with an accuracy competitive with experimental structures in the majority of cases using a novel deep learning architecture. But the accuracy is limited by the fact that no homologous structure is available.
Journal ArticleDOI
Improved protein structure prediction using potentials from deep learning
Andrew W. Senior,Richard Evans,John M. Jumper,James Kirkpatrick,Laurent Sifre,Tim Green,Chongli Qin,Augustin Žídek,Alexander Nelson,Alex Bridgland,Hugo Penedones,Stig Petersen,Karen Simonyan,Steve Crossan,Pushmeet Kohli,David T. Jones,David T. Jones,David Silver,Koray Kavukcuoglu,Demis Hassabis +19 more
TL;DR: It is shown that a neural network can be trained to make accurate predictions of the distances between pairs of residues, which convey more information about the structure than contact predictions, and the resulting potential can be optimized by a simple gradient descent algorithm to generate structures without complex sampling procedures.
Journal ArticleDOI
AlphaFold Protein Structure Database: massively expanding the structural coverage of protein-sequence space with high-accuracy models.
Mihaly Varadi,Stephen Anyango,Mandar Deshpande,Sreenath Nair,Cindy Natassia,Galabina Yordanova,David Yu Yuan,Oana Stroe,Gemma Wood,Agata Laydon,Augustin Žídek,Tim Green,Kathryn Tunyasuvunakool,Stig Petersen,John M. Jumper,Ellen Clancy,Richard E. Green,Ankur Vora,Mira Lutfi,Michael Figurnov,Andrew Cowie,Nicole Hobbs,Pushmeet Kohli,Gerard J. Kleywegt,Ewan Birney,Demis Hassabis,Sameer Velankar +26 more
TL;DR: The AlphaFold Protein Structure Database (AlphaFold DB, https://alphafold.ebi.ac.uk) is an openly accessible, extensive database of high-accuracy protein-structure predictions.
Journal ArticleDOI
Highly accurate protein structure prediction for the human proteome
Kathryn Tunyasuvunakool,Jonas Adler,Zachary Wu,Tim Green,Michal Zielinski,Augustin Žídek,Alex Bridgland,Andrew Cowie,Clemens Meyer,Agata Laydon,Sameer Velankar,Gerard J. Kleywegt,Alex Bateman,Richard Evans,Alexander Pritzel,Michael Figurnov,Olaf Ronneberger,Russell Bates,Simon A. A. Kohl,Anna Potapenko,Andrew J. Ballard,Bernardino Romera-Paredes,Stanislav Nikolov,R. D. Jain,Ellen Clancy,David Reiman,Stig Petersen,Andrew W. Senior,Koray Kavukcuoglu,Ewan Birney,Pushmeet Kohli,John M. Jumper,Demis Hassabis +32 more
TL;DR: The AlphaFold2 dataset as discussed by the authors is a large-scale and high-accuracy structure prediction dataset for protein structures, which is used to evaluate the structural properties of proteins.