S
Stuart Simon
Publications - 2
Citations - 923
Stuart Simon is an academic researcher. The author has contributed to research in topics: Tissue factor pathway inhibitor & Population. The author has an hindex of 2, co-authored 2 publications receiving 893 citations.
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Efficacy and safety of tifacogin (recombinant tissue factor pathway inhibitor) in severe sepsis: a randomized controlled trial.
Edward Abraham,Konrad Reinhart,Steven M. Opal,Ignace Demeyer,Christopher J. Doig,Angel López Rodriguez,Richard Beale,Petr Svoboda,Pierre-François Laterre,Stuart Simon,Bruce Light,Herbert Spapen,Judy Stone,Allan Seibert,Claus Peckelsen,Cathy De Deyne,Russell Postier,Ville Pettilä,Charles L. Sprung,Antonio Artigas,Sandra Percell,Vincent Shu,Christian Zwingelstein,Jeffrey Tobias,Lona Poole,James C. Stolzenbach,Abla A. Creasey +26 more
TL;DR: Treatment with tifacogin had no effect on all-cause mortality in patients with severe sepsis and high INR and tifACogin administration was associated with an increase in risk of bleeding, irrespective of baseline INR.
Efficacy and Safety of Tifacogin (Recombinant Tissue Factor Pathway Inhibitor) in Severe Sepsis
Edward Abraham,Steven M. Opal,Ignace Demeyer,Richard Beale,Petr Svoboda,Stuart Simon,Bruce Light,Judy Stone,Claus Peckelsen,Cathy De Deyne,Ville Pettilä,Charles L. Sprung,Sandra Percell,Vincent Shu,Lona Poole,James C. Stolzenbach,Abla A. Creasey +16 more
TL;DR: The expression and release of tissue factor is a major trigger for the activation of coagulation in patients with sepsis and TFPI forms a complex with tissue factor and blood protease factors leading to inhibition of thrombin generation and fibrin formation.