S
Stuart Trenholm
Researcher at Montreal Neurological Institute and Hospital
Publications - 26
Citations - 1379
Stuart Trenholm is an academic researcher from Montreal Neurological Institute and Hospital. The author has contributed to research in topics: Retina & Retinal degeneration. The author has an hindex of 18, co-authored 25 publications receiving 1116 citations. Previous affiliations of Stuart Trenholm include Friedrich Miescher Institute for Biomedical Research & Dalhousie University.
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Journal ArticleDOI
Single-cell–initiated monosynaptic tracing reveals layer-specific cortical network modules
Adrian Wertz,Stuart Trenholm,Keisuke Yonehara,Daniel Hillier,Zoltan Raics,Marcus Leinweber,Gergely Szalay,Alexander Ghanem,Georg B. Keller,Balázs Rózsa,Karl-Klaus Conzelmann,Botond Roska,Botond Roska +12 more
TL;DR: Single-cell–initiated, monosynaptically restricted retrograde transsynaptic tracing with rabies viruses expressing GCaMP6s is used to image, in vivo, the visual motion–evoked activity of individual layer 2/3 pyramidal neurons and their presynaptic networks across layers in mouse primary visual cortex.
Journal ArticleDOI
Parallel mechanisms encode direction in the retina.
TL;DR: It is demonstrated that morphological asymmetries along with nonlinear dendritic conductances generate a centrifugal (soma-to-dendrite) preference that does not critically depend upon, but works in parallel with the GABAergic circuitry.
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An Intrinsic Neural Oscillator in the Degenerating Mouse Retina
TL;DR: Results indicate that an electrically coupled network of ON cone bipolar/AII amacrine cells constitutes an intrinsic oscillator in the rd1 retina that is likely to drive synaptic activity in downstream circuits.
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Congenital Nystagmus Gene FRMD7 Is Necessary for Establishing a Neuronal Circuit Asymmetry for Direction Selectivity
Keisuke Yonehara,Michele Fiscella,Antonia Drinnenberg,Antonia Drinnenberg,Federico Esposti,Stuart Trenholm,Jacek Krol,Felix Franke,Brigitte Gross Scherf,Akos Kusnyerik,Jan Müller,Arnold Szabo,Josephine Jüttner,Francisco Cordoba,János Németh,Zoltán Zsolt Nagy,Francis L. Munier,Andreas Hierlemann,Botond Roska,Botond Roska +19 more
TL;DR: This work identifies FRMD7 as a key regulator in establishing a neuronal circuit asymmetry, and it suggests the involvement of a specific inhibitory neuron type in the pathophysiology of a neurological disease.
Journal ArticleDOI
Whole-Brain Functional Ultrasound Imaging Reveals Brain Modules for Visuomotor Integration
Emilie Mace,Gabriel Montaldo,Stuart Trenholm,Cameron S. Cowan,Alexandra Brignall,Alan Urban,Botond Roska,Botond Roska +7 more
TL;DR: Functional ultrasound imaging is developed to record whole-brain activity in behaving mice at a resolution of ∼100 μm and identifies functional modules of brain regions involved in sensorimotor integration and provides an experimental approach to monitor whole- brain activity of mice in normal and disease states.