Su-Xian Liu

TL;DR: It is shown that arsenite is in fact a strong dose-dependent mutagen and that it induces mostly large deletion mutations, and Cotreatment of cells with the oxygen radical scavenger dimethyl sulfoxide significantly reduces the mutagenicity of arsenite.

TL;DR: Examination of frequencies and molecular spectrum of S1- mutants induced in human-hamster hybrid (A(L) cells by either a single or an exact number of alpha particles provides direct evidence that a single a particle traversing a nucleus will have a high probability of resulting in a mutation and highlight the need for radiation protection at low doses.

TL;DR: It is shown that mitochondrial damage plays a crucial role in arsenic mutagenicity and that mitochondria are a primary target in arsenic-induced genotoxic response, and that a better understanding of the mutagenic/carcinogenic mechanism of arsenic should provide a basis for better interventional approach in both treatment and prevention of arsenic- induced cancer.

TL;DR: This new series of bioreductive compounds may be effective in cancer therapy, particularly the lead compound RB 90740, and the oncogenic potential of these compounds is similar to that for other cancer therapies.

TL;DR: In this article , the function of mitochondrial dysfunction in nephrotoxicity generated by depleted uranium (DU) and confirm the latent mechanism was elucidated and the mechanism of kidney toxicity was further explored.