S
Sucha Sudarsanam
Researcher at Pfizer
Publications - 38
Citations - 9989
Sucha Sudarsanam is an academic researcher from Pfizer. The author has contributed to research in topics: Protein structure & Kinase. The author has an hindex of 18, co-authored 38 publications receiving 9333 citations. Previous affiliations of Sucha Sudarsanam include Seattle University & Pharmacia.
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Journal ArticleDOI
The Protein Kinase Complement of the Human Genome
TL;DR: The protein kinase complement of the human genome is catalogued using public and proprietary genomic, complementary DNA, and expressed sequence tag sequences to provide a starting point for comprehensive analysis of protein phosphorylation in normal and disease states and a detailed view of the current state of human genome analysis through a focus on one large gene family.
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Evolution of protein kinase signaling from yeast to man.
TL;DR: Fly and human share several kinase families involved in immunity, neurobiology, cell cycle and morphogenesis that are absent from worm, suggesting that these functions might have evolved after the divergence of nematodes from the main metazoan lineage.
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The mouse kinome: Discovery and comparative genomics of all mouse protein kinases
TL;DR: The full protein kinase (PK) complement (kinome) of mouse is determined, which includes many novel kinases and corrections or extensions to >150 published sequences, and links 163 kinases to mutant phenotypes and unlocks the use of mouse genetics to determine functions of orthologous human kinases.
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The protein kinases of Caenorhabditis elegans: A model for signal transduction in multicellular organisms
TL;DR: The richness of phosphorylation-dependent signaling pathways in worms is further supported with the identification of 185 protein phosphatases and 128 phosphoprotein-binding domains in the worm genome.
Journal Article
Interactions between traditional Chinese medicines and Western therapeutics.
TL;DR: Improvements in the knowledge of the molecular targets and metabolic pathways, as well as of the synergistic and inhibitory effects associated with important phytochemicals from herbs and herbal formulations, will lead to the development of rational approaches for the safe combination of healthcare systems from different cultures.