Sudha Agarwal

TL;DR: Electrospinning was combined with salt leaching to produce a scaffold having deliberate, engineered delaminations to facilitate infiltration while retaining its extracellular matrix-like character, and the result provides a convincing illustration of the ability of mammalian cells to interact with appropriately tailored electrospun matrices.

TL;DR: It is demonstrated that sanguinarine is a potent suppressor of NF-κB activation and it acts at a step prior to IκBα phosphorylation, which suggests a critical sulfhydryl group is involved in NF-kkB activation.

TL;DR: Electrospun poly(epsilon-caprolactone) (PCL) scaffolds were used as a 3-D microenvironment for osteoblast culture and provide the molecular basis for the experimental and clinical observations that appropriate physical activities or microscale compressive loading can enhance fracture healing due in part to the anabolic osteogenic effects.

TL;DR: The observations suggest that biodegradable peptide-based urethane polymers can be synthesized which may pave their way for possible use in tissue engineering applications.

TL;DR: The results for chondrogenic and osteogenic differentiation of progenitor cells on each scaffold indicate that the lower modulus PCL fibers provided more appropriate microenvironments forchondrogenesis, and the microstructural stiffness/modules of a scaffold and the pliability of individual fibers may play a critical role in controlling stem cell differentiation.